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Death of a cell or group of cells under either normal or pathologic conditions.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Some of the cutaneous markers of diabetes mellitus like necrobiosis lipoidica diabeticorum, diabetic bullae, acquired perforating dermatosis and stiff skin syndrome is not seen in our study.
Biopharmaceutical company Processa Pharmaceuticals Inc (OTC:PCSA) disclosed on Friday the receipt of US Food and Drug Administration (FDA) orphan-drug designation for its leading clinical compound PCS499 for treatment of Necrobiosis Lipoidica (NL).
M2 PHARMA-June 25, 2018-Processa wins US FDA orphan designation status for PCS499 for Necrobiosis Lipoidica (NL)
For ulcerative lesions of PG, frequent differential diagnosis include infective such as necrotizing fascitis, vascular occlusive or venous disease, necrobiosis lipoidica, livedoid vasculitis, sarcoidosis, or cutaneous malignancies such as squamous cell carcinoma and basal cell carcinoma, vasculitic processes such as Wegener's, malignancy such as lymphoma or leukemia, and pustular drug reactions.
Localized granuloma annulare must be differentiated from the most common annular lesion, tinea corporis, as well as other annular lesions, including necrobiosis lipoidica and erythema migrans.
The absence of diabetic thick skin and necrobiosis lipoidica diabeticorum (NLD) in the present study when compared to other studies,2,8,23 (Table 5) is mainly due to short duration of DM in the majority of the patients.
Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. Br J Dermatol.
Necrobiosis lipoidica (NL) is another necrobiotic disorder with lesions occurring mainly over legs but can involve other sites as well and is seen in 0.3-1.6% of diabetic patients.9 In this study, necrobiosis lipoidica was seen in 1 (0.3%) case.