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Death of a cell or group of cells under either normal or pathologic conditions.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

References in periodicals archive ?
Resolution of necrobiosis lipoidica with exclusive clobetasol propionate treatment.
Pentoxifylline for necrobiosis lipoidica diabeticorum.
PUVA therapy in necrobiosis lipoidica diabeticorum.