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Death of a cell or group of cells under either normal or pathologic conditions.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

References in periodicals archive ?
These are Tuberculous granulomas, Lepromatous granulomas, Foreign Body granulomas, Necrobiotic granulomas, Suppurative granulomas, Sarcoidal granulomas and Xanthgranulomas/ malakoplakia.
Granuloma annulare is a idiopathic necrobiotic disorder which has many predisposing factors.
In rheumatoid patients, nodular lung disease in the form of necrobiotic ("rheumatoid") nodules can be encountered.
It is characterized by necrobiotic changes in the dermis that extend down to the perichondrium; associated alterations are seen in the cartilaginous plate.
Necrobiotic xanthogranuloma with paraproteinemia is a paraneoplastic disorder characterized is a paraneoplastic disorder characterized by progressive development of widespread nodules and plaques with ulceration and central atrophy.
Differential diagnosis will be tendinous xanthoma, necrobiotic granuloma, foreign body granuloma, epidermoid cyst, knuckle pad, fibroma of tendon sheath, lipoma and ganglion cyst [8].
These necrobiotic nodules are often located subpleurally and surrounded by palisading histiocytes and giant cells.
Variations of enzyme activities in the haemocytes of scallop Chlamysfarreri after infection with the acute virus necrobiotic virus (AVNV).
Noninfectious cystitis includes interstitial cystitis, eosinophilic cystitis, drug-induced cystitis, and postsurgical necrobiotic granulomas.
Necrobiotic granulomas of the uterine cervix: a probable postoperative reaction.
Granulomatous bronchiolitis with necrobiotic pulmonary nodules in Crohn's disease.