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Death of a cell or group of cells under either normal or pathologic conditions.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

References in periodicals archive ?
Histologically, epithelioid sarcoma and isolated necrobiotic granulomas may also be similar.
Adult orbital xanthogranulomatous disease presents with variable clinical features from which 4 subtypes are subclassified: adult-onset xanthogranuloma (AOX), necrobiotic xanthogranuloma (NBX), Erdheim-Chester disease (ECD), and adultonset asthma and periocular xanthogranuloma (AAPOX).
Necrobiotic xanthogranuloma is characterized by the presence of subcutaneous skin lesions that tend to ulcerate and become fibrotic.
Small nerve units were also caught up in this scarifying process, which failed to show necrobiotic foci, fibrinoid material, or nuclear dust.
Ulceration and necrosis are typical, with the frequent central necrosis (Figure 2), resulting in a pseudogranulomatous appearance, which can mimic benign necrobiotic granulomatous lesions.
69) Colloidal iron or Alcian blue stains may reveal mucin in the central necrobiotic foci of granuloma annulare, (70) but in our experience that finding is not typical of ES.