necrotizing fasciitis


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Related to necrotizing fasciitis: necrotizing enterocolitis

necrotizing fasciitis,

a quickly progressing infection of the skin that spreads along the fascia, the tissue that covers the muscles. (Necrotizing infections that spread along the outer skin layers are known as necrotizing cellulitis.) Necrotizing fasciitis is most commonly caused by toxins released by a strain of Group A streptococcal bacteria (S. pyrogenes; see streptococcusstreptococcus
, any of a group of gram-positive bacteria, genus Streptococcus, some of which cause disease. Streptococci are spherical and divide by fission, but they remain attached and so grow in beadlike chains.
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), but it also may be caused by Staphylococcus aureus (see staphylococcusstaphylococcus
, any of the pathogenic bacteria, parasitic to humans, that belong to the genus Staphylococcus. The spherical bacterial cells (cocci) typically occur in irregular clusters [Gr. staphyle=bunch of grapes].
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); other bacteria may also be present.

Popularly known as "flesh-eating disease," the infection typically begins as a warm, very painful red swelling, sometimes at the site of a minor injury. Patients usually have a high fever and may feel ill, dizzy, and confused; the infection spreads rapidly, and tissue in older infected areas turns purplish or black as it dies. Necrotizing fasciitis is treated with surgery (to remove infected tissue) and intravenous antibiotics (high-dose penicillin and clindamycin). If not treated promptly, the toxins produced by the bacteria can cause septic shock and lead to death within 24 hours; roughly 30% of infected patients die.

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Despite a series of reports about necrotizing fasciitis over the past months, the CDC noted the infection remains rare in the U.S.
Necrotizing fasciitis is an infection that is caused by bacteria that stops blood circulation and causes tissues to die and skin to decay.
The term "necrotizing fasciitis" was coined by Wilson in 1952 to emphasize the features of fascia necrosis, observed when there is spread of infection along the fascia planes, and the nonspecific nature of the causative microbes.
The first known report of necrotizing fasciitis, also known colloquially as a disease of "flesh-eating bacteria," dates to 500 BC by Hippocrates.
In conclusion, we present a rare case of severe pyelonephritis with nontraumatic renal rupture leading to necrotizing fasciitis with osteomyelitis of the lower limb.
baumannii associated with necrotizing fasciitis, after open reduction and internal fixation (ORIF) of multiple fractures after polytrauma.
Necrotizing fasciitis is a life-threatening, rapidly progressive infection [1] characterized by widespread necrosis of the subcutaneous tissue and fascia, with associated systemic toxicity and extension along fascial planes [2, 3].
Predictors of mortality in patients with Necrotizing Fasciitis. Am J Emerg Med 2008;26(2):170-5.
The most important laboratory scoring system for early diagnosis is the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score.
These life-threatening infections have varied presentations from cellulitis, necrotizing fasciitis, and myonecrosis.
Besides rituximab-induced necrotizing fasciitis, other drug-related necrotizing fasciitis cases in immunocompromised patients have been previously reported in the literature, including associations with systemic corticosteroids [23], tumor necrosis factor-alpha (TNF-[alpha]) inhibitors [24], non-steroidal anti-inflammatory drugs [25], and other immunosuppressants such as tocilizumab [26] and bortezomib [27].
To put it in a "good news, bad news" perspective: Necrotizing fasciitis is statistically rare and not contagious; however, if it's not identified, and treatment hasn't begun, within a few days, it can be fatal in up to 25 percent of cases.

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