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Inflammation of the pancreas.



acute or chronic inflammation of the pancreas.

Acute pancreatitis may be edematous, hemorrhagic, necrotic, or purulent. It is caused by overeating; by diseases of the stomach, duodenum, biliary tract, or liver; or by stenosis of the gland’s ducts. In acute pancreatitis the pancreas is digested by its own enzymes—trypsin, chymotrypsin, and lipase. When the gland’s tissue decomposes, kinins are released. They decrease arterial pressure and are a factor in blood circulation disorder of both organic and reflex origin in the pancreas. The kinins also cause bile to flow into the gland’s ducts, which damages their walls.

Acute pancreatitis may be marked by very severe abdominal pains, persistent vomiting, and collapse. Complications are peritonitis, abscesses, cysts of the gland, and diabetes mellitus. The disease is treated by narcotics, antibiotics, vasoconstrictors, and such antienzyme preparations as trasilol and contrical and by A. V. Vishnevskii’s paranephric novocain blockade. Serious complications are treated surgically.

In chronic pancreatitis, the gland’s external and internal secretions gradually become insufficient. The disease is treated by diet, antispasmodics, substitutes, cholegogues, antibiotics, and antienzyme preparations. During periods of remission, the patient may receive treatment at a health resort.


Shelagurov, A. A. Bolezni podzheludochnoi zhelezy. Moscow, 1970.


References in periodicals archive ?
Alexandre JH, Guerrieri MT Role of total pancreatectomy in the treatment of necrotizing pancreatitis.
Based on post-marketing data, exenatide has been associated with acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis.
to "add stronger and more prominent warnings" about the risk of acute hemorrhagic and necrotizing pancreatitis to the drug's precautions section.
r] 13 000) of calcitonin with a long half-life in the systemic circulation, was found in high concentrations in patients with severe bacterial or fungal infections and sepsis (7), and it was reported as a marker in assessing the infection of necrotizing pancreatitis in late-stage disease (8) and in evaluating the biliary origin of the AP (9).
Empiric use of parental antibiotics in acute necrotizing pancreatitis is recommended whether infection is present or not.
There have been postmarketing reports of acute pancreatitis, including fatal and nonfatal hemorrhagic or necrotizing pancreatitis, in patients taking JANUVIA.
Necrotizing pancreatitis has much higher morbidity and mortality than does interstitial pancreatitis (about 17% vs.
Also, only 55% correlated necrotizing pancreatitis with systematic inflammatory response syndrome.
The infection rate was similar in the 41 prophylaxis and 35 placebo patients who had necrotizing pancreatitis.

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