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Related to necrotizing vasculitis: Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy


Inflammation of a blood vessel or a lymph vessel. Also known as angiitis.



inflammation of the walls of the small blood vessels. Vasculitis is usually caused by influenza, typhus, streptococcal infections (erysipelas, angina), or physical factors (frostbite, burns). Vasculitis may also arise as a secondary manifestation of collagen or allergic diseases, such as rheumatism, lupus erythematosus, rheumatoid arthritis, and serum and drug diseases. Sometimes vasculitis may be caused by a combination of some of these factors. The most usual, and often the only, external symptom of vasculitis is affection of the skin (hemorrhages, rashes, necrotic nidi, and so forth). As vasculitis progresses, thrombi may form in the vessels (thrombovasculitis), necrosis of the walls of the vessels may occur, and aneurysms may form. In the final stage of vasculitis complete occlusion of the vessels by a thrombus may occur, which leads to the disrupting of nutrition to the corresponding tissues and organs, bursting of aneurysms, and hemorrhaging into the surrounding tissues. Vasculitis is classified according to site as cutaneous and visceral; the latter predominantly affects the vessels of serous and mucous membranes of internal organs, such as the liver and kidneys. Treatment consists of the removal of the main disease causing the vasculitis.


Davydovskii, I. V. Patoligicheskaia anatomiia i patogenez boleznei cheloveka, 3rd ed., vols. 1-2. Moscow, 1956-58.


References in periodicals archive ?
The organs affected varied even in this small set of animals, but all dogs had necrotizing vasculitis and hemorrhage, and all but 1 had lymphadenitis and granulomatous disease.
B19 infections in our cases are likely to be acute or acute on a chronic infection because of the presence of DNAemia which persisted for one month in first case who had also suffered from necrotizing vasculitis of the skin.
The classic histologic picture of Wegener granulomatosis consists of necrotizing granulomatous inflammation accompanied by necrotizing vasculitis (4,135,136) (Figure 7, A, C, and E).
During a medical screening program for former Department of Energy (DOE) workers by the Johns Hopkins University Former Los Alamos National Laboratory (LANL) Workers Program (Espanola, NM) a 63-year-old white male expressed concern that his diagnoses of microscopic polyangiitis, systemic necrotizing vasculitis, leukocytoclastic vasculitis, pulmonary interstitial fibrosis, and glomerulonephritis were related to silica exposure.
Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.
Necrotizing vasculitis is the sine qua non of Wegener granulomatosis, although it may be neither a prominent feature nor present in a subset of lung biopsies.
Necrotizing vasculitis persists as an extremely serious condition where complicated diagnostic and treatment decisions may need to be made on an urgent and chronic basis.
The first patient, an African American woman, presented with recurrent necrotizing vasculitis of her ears (Figure 1) and was found to have positive serology for cytoplasmic antineutrophil cytoplasmic antibody, human neutrophil elastase antibody, and anticardiolipin antibody.
Small and medium-sized vessels showed necrotizing vasculitis with focal fibrinoid necrosis and mural inflammation.
Calciphylaxis: A condition mimicking necrotizing vasculitis.
Wegener's granulomatosis is a systemic necrotizing vasculitis that primarily affects the lungs and kidneys.