negative regulator

negative regulator

[′neg·əd·iv ‚reg·yə′lād·ər]
(genetics)
Any regulator that acts to prevent transcription or translation.
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References in periodicals archive ?
Accordingly, a PILS-dependent substrate could be a negative regulator of ABP1 function in the ER.
One of my major contributions to this field was the discovery of the vitamin D hormone as a negative regulator of the renin-angiotensin system.
Observations in animal studies suggest that vitamin D is a negative regulator of the RAS, which is responsible for volume and blood pressure homeostasis and is a pivotal regulatory system in heart failure.
CTLA4 is expressed on T cells, where it functions as a fundamental negative regulator of T-cell activation.
PTP-1B is a protein tyrosine phosphatase enzyme that is an important negative regulator of insulin signaling and leptin signaling.
Castrillon and colleagues have previously shown that the FOXO3 gene is part of the trigger mechanism that results in follicle activation and is an essential negative regulator of this process.
tcdC is considered a negative regulator of the production of toxins A and B, but whether this 18-bp deletion results in a nonfunctional product is unknown (3).
AKB9778 is a first-in-class small molecule that works by inhibiting the Human Protein Tyrosine Phosphatase (HPTP, also known as VE-PTP, or vascular endothelial protein tyrosine phosphatase) enzyme, a negative regulator of the Tie2 receptor.
CAT-2003 also had positive effects on other biomarkers, including reductions in apolipoprotein C-III (ApoC-III), a negative regulator of lipoprotein lipase, and apolipoprotein B (ApoB), the lipoprotein associated with VLDL and LDL cholesterol.
Osteocalcin might be a negative regulator of bone formation," says Stavros C.
AKB9778 is a first-in-class small molecule that works by inhibiting the Human Protein Tyrosine Phosphatase (HPTP) enzyme, which acts as a negative regulator of the Tie2 receptor.
We demonstrated that MEF2 controls the expression of caveolin3, an inhibitor of myostatin, a negative regulator of muscle mass.

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