AKB-9778 binds to and inhibits vascular endothelial protein tyrosine phosphatase (VE-PTP), an important negative regulator
Hematopoietic Progenitor Kinase 1, a member of the MAP4K family, is an intracellular negative regulator
of T cell proliferation and signaling and plays a key role in dendritic cell activation.
Peptidoglycan recognition protein-S5 functions as a negative regulator
of the antimicrobial peptide pathway in the silkworm, Bombyx mori.
LIN 28A; a protein that binds small RNAs, a negative regulator
of let-7 family of micro RNAs which act as tumour suppressor micro RNAs is now used as an Immunohistochemical marker (6,7).
The studies also identified a negative regulator
of the immune checkpoint PD-L1, a major clinical target of cancer immunotherapy.
Immunohistochemistry staining of MDM-2, a negative regulator
of the p53 tumor suppressor, and p16 have emerged as markers for ALT/WDL.
MafB is a negative regulator
of receptor activator of nuclear factor kB ligand(RANKL) mediated osteoclast differentiation .
Insulin resistance may be induced by isoproterenol via several mechanisms, including inhibition of resistin gene expression , inhibition of insulin mediated tyrosine phosphorylation of the insulin receptor , inhibition of localization of the glut-4 receptor to the cell wall , and activation of gene expression of SOCS-3 (suppressor of cytokine signaling-3), a negative regulator
of insulin .
Moreover, miR-124 is a negative regulator
of osteoclastogenesis in mouse BMMs.
The team led by Choi Kang-yeol of Yonsei University discovered that a protein called CXXC5 acts as negative regulator
of the Wnt signaling pathway inside of a cell that is linked to follicle development and hair regeneration in adults, the Ministry of Science and ICT said.
Hepcidin; an anti-microbial peptide of 25 amino acids (Park et al., 2001); formerly known as LEAP-1(Liver-expressed antimicrobial peptide) (Krause et al., 2000), is a negative regulator
of iron metabolism (Lesbordes-Brion et al., 2006; Nicolas et al., 2001; Nicolas et al., 2002).
CTLA-4 is a negative regulator
of T-cell activation.