negative regulator

negative regulator

[′neg·əd·iv ‚reg·yə′lād·ər]
(genetics)
Any regulator that acts to prevent transcription or translation.
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References in periodicals archive ?
AKB-9778, being developed as a subcutaneous injection for the treatment of non-proliferative diabetic retinopathy, binds to and inhibits vascular endothelial phosphotyrosine phosphatase (VE-PTP), the most critical negative regulator of Tie2.
The team led by Choi Kang-yeol of Yonsei University discovered that a protein called CXXC5 acts as negative regulator of the Wnt signaling pathway inside of a cell that is linked to follicle development and hair regeneration in adults, the Ministry of Science and ICT said.
These modifications include addition of 4-amino-4-deoxy-L-arabinose or phosphoethanolamine caused by chromosomal mutations in genes encoding the 2-component systems PhoPQ and PmrAB, or mutations in the mgrB gene, a negative regulator of PhoPQ (1).
Recently, melatonin was shown to directly influence insulin biosynthesis and secretion under ER stress via the RNA-binding protein human antigen D (HuD) in rat pancreatic INS-1E cells, suggesting that nuclear HuD may be an important negative regulator in insulin production and secretion [13].
Is a Negative Regulator of ABA Signaling" [1], the name of the sixth author was incorrectly written as Weiming Jiang while the correct name is Weimin Jiang.
Accordingly, a PILS-dependent substrate could be a negative regulator of ABP1 function in the ER.
2 B7-H1(PD-L1) is a negative regulator of the immune response in this family which is important for formation and maintenance of maternal immunological tolerance of the fetal placenta.
It binds to Osteopontin that interacts with osteoclasts and acts as a negative regulator of mineralisation.
Citation: "The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor;" Anne E.
NOX-generated ROS affect PI3K/Akt signaling by causing the inactivation of the PTEN protein, an important tumor suppressor and negative regulator of the pathway, by oxidizing a cysteine residue in the protein, which inactivates its function.
Observations in animal studies suggest that vitamin D is a negative regulator of the RAS, which is responsible for volume and blood pressure homeostasis and is a pivotal regulatory system in heart failure.

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