negative selection


Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.

negative selection

[¦neg·əd·iv si′lek·shən]
(immunology)
The death of autoimmune lymphocytes shortly after they develop. Also known as clonal deletion.
Mentioned in ?
References in periodicals archive ?
Alternatively, there may be negative selection of immigrants into enclaves: those immigrants with lower unobservable skills may be more likely to join an enclave community.
Continued selection for resistance with or without hardening can lead to a negative selection response that is no longer evident once selection is relaxed for a generation.
Mean mass of dispersed seeds, sampled just after the ripe fruit crops have been exhausted by frugivores, was significantly smaller than that of seeds available at the start of the fruiting season (Table 4), suggesting a realized negative selection pattern on seed size by frugivorous birds after the selection episode defined by the fruit removal phase.
Thus, negative selection on pv during cooler spring conditions does not appear consistent with our understanding of the thermoregulatory effects of this trait.
Because of their thermo-regulatory effects (Kingsolver 1987), hb and pv were predicted to experience negative selection during the warm summer conditions at this site.
When mixed with cord blood, the proprietary reagent within PrepaCyte-CB rapidly facilitates a negative selection process causing unwanted cells, such as RBC, to settle to the bottom of the bag -- leaving viable cells unmodified and available for easy collection in the upper fraction of the solution.
Using historical information, recent trading patterns and real-time market data, MAKE sizes and distributes child orders at multiple price levels and across destinations, controlling adverse and negative selection while reducing exposure to signaling, gaming, and predatory techniques.
Importantly, the PrepaCyte platform is a non-particle-based separation medium that separates cells using negative selection.
This process also allows the Investable Index to minimize negative selection bias in order to produce an Investable benchmark that best reflects the hedge fund universe.
To evaluate the combined effects of IL-21 and rituximab in vitro, human NK cells were prepared by negative selection from peripheral blood mononuclear cells of healthy donors and cultured for 3 days +/- IL-21.
The Isolex(R) 300i System capable of sequential positive and negative selection used in this study is commercially available in Europe.
Because it employs negative selection, in which immunomagnetic beads are attached to unwanted cells to facilitate their removal, the Kit also avoids potential interference with subsequent dendritic cell generation caused by residual antibodies on the cell surface.