negative selection


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negative selection

[¦neg·əd·iv si′lek·shən]
(immunology)
The death of autoimmune lymphocytes shortly after they develop. Also known as clonal deletion.
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11) The cost of migration was lower in the past, which may have allowed the negative selection predicted by the Roy model to be manifest.
Aziz, Mostafa Salama, Aboul ella Hassanien, Sanaa EL-Ola Hanafi (2012) Detectors Generation using Genetic Algorithm for a Negative Selection Inspired Anomaly Network Intrusion Detection System", In proceeding of: IEEE FedCSIS, At Wroclaw, Poland, pp.
It has been postulated that T-cell alteration occurs indirectly through other cells (Kerkvliet 2002), possibly during negative selection (Fisher et al.
Negative Selection is based on the principles of self-nonself discrimination that take place in the immune system.
If concern about negative selection and gaming are compared with fear of crime in the neighbourhood, the antidote is to walk through the layout, population and services of each neighbourhood, giving traders the choice of defence mechanisms proportionate to their order's size and difficulty at any given moment.
In this experiment, the knock-in vector was constructed using the porcine [beta]-casein genome locus, neo gene as the positive selection marker and diphtheria toxin A as the negative selection marker.
At higher urgency levels, with more emphasis on minimizing negative selection, child orders will tend to be larger and more frequent.
Tregs are critical in the suppression of autoreactive lymphocytes that have escaped elimination through negative selection in the thymus (Cupedo et al.
The company's HDM technology is the subject of United States Patent 5,576,185, issued in 1996, entitled "Method of Positive or Negative Selection of a Population or Sub Population of a Sample Utilizing Particles and Gravity Sedimentation.
When mixed with cord blood, the proprietary reagent within PrepaCyte-CB rapidly facilitates a negative selection process.
When mixed with cord blood, the proprietary reagent within PrepaCyte-CB rapidly facilitates a negative selection process causing unwanted cells, such as RBC, to settle to the bottom of the bag -- leaving viable cells unmodified and available for easy collection in the upper fraction of the solution.
In the agreement announced today, Biogen renewed its license to use Lexicon's positive negative selection technology and received non-exclusive rights under the patent covering Lexicon's isogenic DNA gene targeting technology.