negative selection


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negative selection

[¦neg·əd·iv si′lek·shən]
(immunology)
The death of autoimmune lymphocytes shortly after they develop. Also known as clonal deletion.
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Useful variability is maintained from generation to generation since only negative selection is carried out in the segregating generations and selection for yield is applied when the materials are in advanced homozygosity.
Ivlev's modified electivity indices show that Horsethief Spring salamanders exhibited moderate positive selection for Diptera, little selection either way for Trichoptera and Plecoptera and moderate negative selection for Isopoda (Table 2).
Thus, negative selection on locust potentially reflected selection against nest site choices that were higher on the vegetation gradient and away from the preferred microhabitat of maple, rather than selection on choice of locust per se.
It is not known how much of this deletion can be attributed to negative selection, but the proportion is thought to be sizable.
This group also seemingly drives the negative selection result.
In fact, good institutional care can and does appear to produce a reasonable number of "successes" --however that outcome is defined--particularly considering the strong negative selection of children who enter the foster-care system.
Using the SME Criteria, we determine jurisdiction-specific probabilities of default, and use bank internal ratings to identify the effect of positive or negative selection compared to the historical performance of the originating bank.
In order to eliminate the aptamers capable of binding both cells, counter SELEX (negative selection) was performed regularly on PC-3 cell lines after third SELEX.
The knock-in vector was constructed using 5' and 3' homologous arms from [beta]-casein genomic DNA with human FGF2 or EGFP, polyA signal, positive and negative selection marker.
In addition, due to introducing network compression, negative selection, and other operators, ai-Net can maintain the diversity of the population and reduce the possibility of being trapped into a local minimum.
The first round of negative selection [Round 1(-)] was performed by incubating Round 1(+) enriched ssDNA with 50 [micro]L (no bromacil and 200 [micro].g magnetic beads) immobilization substrate (IS) in a total volume of 100 [micro]L SB at room temperature for 24 hours with rotation.