negative staining

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negative staining

[′neg·əd·iv ′stān·iŋ]
(biology)
A method in microscopy for demonstrating the form of cells, bacteria, and other small objects by staining the ground rather than the objects.
References in periodicals archive ?
There were several interesting components to this case that we sought to further investigate in the literature, particularly the incidence of radiotherapy-induced melanoma and melanoma diagnosed in the presence of a negative stain for S-100 protein.
However, the current situation is likely to leave a very negative stain on Turkish politics and even on society as a whole.
The larger diameter can be explained by flattening of the vesicles upon drying down in the negative stain (see Discussion).
The liposomes and their complexes with PS/ON were also characterized by using a negative stain electron microscope.
The evaluation of different heavy metal salts for negative staining showed that the quality of EM as a diagnostic method does not depend on the negative stain used.
1 together with a negative stain of GATA3 support prostate carcinoma, and diagnosis of urothelial carcinoma would be supported by GATA3 (Figure 7, D) positivity and negative stain of P501S and NKX3.
Thin section and negative stain electron microscopy (EM) examination of viruses grown in cultured cells have been instrumental in determining an etiologic agent in numerous disease outbreaks caused by previously unknown viruses.
Grids with adherent axoplasm are immediately transferred to a 10-[mu]l droplet of motility buffer (3) and then passaged through three 10-[mu]l droplets of 1mg/ml bacitracin and three droplets of 2% aqueous uranyl acetate for 1 min each as a negative stain.
Negative stain electron microscopy was performed by using cell culture supernatant.
In this case the absence of lymphoglandular bodies and the presence of large clusters of cohesive cells and a negative stain for LCA ruled out a lymphoma.
After a simple and fast negative stain preparation, the undirected, "open view" of electron microscopy allows rapid morphologic identification and differential diagnosis of different agents contained in the specimen.