negative staining

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negative staining

[′neg·əd·iv ′stān·iŋ]
(biology)
A method in microscopy for demonstrating the form of cells, bacteria, and other small objects by staining the ground rather than the objects.
References in periodicals archive ?
After a simple and fast negative stain preparation, the undirected, "open view" of electron microscopy allows rapid morphologic identification and differential diagnosis of different agents contained in the specimen.
Rotavirus infections were diagnosed by negative stain electron microscopy.
A negative stain preparation may be made and a result could be obtained within 5 minutes of the specimen's arrival in the EM laboratory.
Tumor type CD147 HS P value 0 1 2 3 4 6 LM 8 2 6 0 4 0 .000 STUMP 1 0 2 1 8 9 ULMS 4 1 4 2 4 11 Total 13 3 12 3 16 20 Tumor type CD147 EL P value Total Neg LE HE LM 8 8 4 .000 20 STUMP 1 3 17 21 ULMS 4 7 15 26 Total 13 18 36 67 LM= leiomyoma; STUMP= smooth muscle tumor of uncertain malignant potential; ULMS= uterine leiomyosarcoma; HS= histologic score; EL: expression level; Neg= negative stain. P value < 0.05 is significant using one way ANOVA and post Hoc multiple comparisons.
A negative stain for cytokeratin excludes a carcinoma.
Additional germ cell neoplasia in situ was excluded by negative stain for PLAP.
There were several interesting components to this case that we sought to further investigate in the literature, particularly the incidence of radiotherapy-induced melanoma and melanoma diagnosed in the presence of a negative stain for S-100 protein.
However, the current situation is likely to leave a very negative stain on Turkish politics and even on society as a whole.
Negative stain: Drops (10 [micro]l) of each SV fraction were placed on Parafilm in a covered, humidified petri dish.
The liposomes and their complexes with PS/ON were also characterized by using a negative stain electron microscope.
The evaluation of different heavy metal salts for negative staining showed that the quality of EM as a diagnostic method does not depend on the negative stain used.