Doctors and nurses are used to seeing and hearing negative trials
(there are plenty of negative or inconclusive pharma studies).
Ben Goldacre's talk at the New York City Skeptics Society, where he expressed his concern about pharma companies hiding negative trial
"The point is, this was not a slam-dunk negative trial
, but it ended up getting reported that way."
Panelists at the meeting said they were not comfortable drawing any conclusions from analyses of patient subgroups in a negative trial
. They voted 13-0 that the FDA should require Abbott to conduct a study to test the hypothesis that add-on therapy with fenofibric acid, compared with placebo, significantly lowers the risk of major adverse cardiovascular events in high-risk patients who have reached their LDL cholesterol goal with a statin but have residual high serum TG and low serum HDL cholesterol levels.
Rather than being seen as a negative trial
, the study appears to speak to the usefulness of structured, individualized weekly CBT, said Dr.
was already growing at a rate of 109% per year, but the publicity of this negative trial
increased growth by an additional 46% in the week immediately following the publication of the negative HRT study.
Since this was a negative trial
(showing no difference between the treatment and control groups), it is important that the study was adequately powered to not miss a true difference.
In the wake of yet another negative trial
, Pfizer has discontinued research on bapineuzumab, a monoclonal antibody designed to target amyloid beta plaques in the brains of patients with Alzheimer's disease.
"In terms of primary analysis and primary end point, this is a negative trial
The new EVEREST analysis contains an important message for clinical trialists: Using the signs and symptoms of congestion as a key target for treatment during hospitalization as well as the standard end point in acute heart failure studies, as has been common until now, is a recipe for a negative trial
Based on extensive post hoc analysis of the phase II data, investigators identified factors that could have contributed to the negative trial
and redesigned the study accordingly.
Within the atypical antipsychotic class, there has been only one positive trial for risperidone (Risperdal) and one negative trial