neogenesis


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neogenesis

[¦nē·ō′jen·ə·səs]
(geology)
The formation of new minerals, as by diagenesis or metamorphism. Also known as neoformation.
References in periodicals archive ?
Exendin-4 stimulates both betacell replication and neogenesis, resulting in increased beta-cell mass and improved tolerance in diabetic rats.
The planned acquisition of NeoGenesis will help strengthen the discovery capabilities of Schering-Plough, as we secure ownership of innovative drug discovery technology and intellectual property," said Fred Hassan, chairman and chief executive officer, Schering-Plough Corporation.
Though terms of the deal were not disclosed, the move is a multiyear agreement in which NeoGenesis will receive funding and payments from Amgen for achieving research milestones.
It has been found that the ligaments and capsule will stretch under gradual tension to improve joint contractures, while nerves, vessels, and muscle have been shown to stretch by local neogenesis.
Cancers are hypoxic for two reasons: the capillaries in cancers are formed by a process known as neogenesis (the generation of new blood vessels), resulting in capillaries that have a tortuous configuration or distorted path providing less oxygen to the cells; and the metabolic processes requiring oxygen (the TCA cycle) has been shut down by the cancer itself to avoid destruction by reactive oxygen species (ROS) generated by mitochondria functioning under hypoxic conditions.
11) This may represent ectopic lymphoid neogenesis (tertiary lymphoid organs) in which interactions between antigen-presenting cells and T cells can occur, potentially promoting proatherosclerotic adaptive immune responses or even activating inhibitory regulatory immune responses.
and NeoGenesis Pharmaceuticals announced Monday that they have signed an agreement to develop drugs targeting cancer and other diseases that affect the brain.
Oxford's proteomics collaborations with major pharmaceutical and biotechnology companies include Bayer, Pioneer Hi-Bred/DuPont, Medarex/GenMab, GlaxoSmithKline, NeoGenesis and Pfizer.
Novel approaches to insulin delivery and disease modification: Inhaled insulin, buccal delivery, anti-CD3 MAbs, immunotherapies, preservation of beta-cell mass and function, vaccines, islet-cell neogenesis.
Recent data suggest that the presence of anti-nuclear antibody (ANA) positivity and the age of onset correlate better with clinically relevant phenotypes, risk of uveitis, expression of genes related to humoral immunity, and the presence of synovial lymphoid neogenesis.
CureDM's technology, Pancreate(TM) targets this causative aspect of the disease by its inherent mechanism of action to repopulate the pancreas with new islet structures by a process known as islet neogenesis.
Oxford also recently announced a high-throughput "targets to leads" collaboration with NeoGenesis (Cambridge, MA).