neomycin

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neomycin

neomycin (nēˌōmīˈsĭn), broad spectrum antibiotic effective against both gram positive and gram negative bacteria (see Gram's stain). It interferes with protein synthesis in sensitive bacterial cells such as species of Proteus and Staphylococcus. Neomycin is mainly used topically in the treatment of skin and mucous membrane infections, wounds, and burns. Although it is also used systemically, it is highly toxic. Neomycin was first isolated in 1949 by the American microbiologist Selman Waksman from a strain of the bacterial species Streptomyces fradiae.

neomycin

[¦nē·ə¦mīs·ən]

(microbiology)

The collective name for several colorless antibiotics produced by a strain of Streptomyces fradiae; the commercial fraction (C₂₃H₄₆N₆O₁₃) has a broad spectrum of activity.

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Seven different dosage levels of chloramphenicol, dihydrostreptomycin sulfate, neomycin, penicillin G, streptomycin sulfate, penicillin G + streptomycin sulfate and penicillin G + streptomycin sulfate + chloramphenicol were added to each culture of microalgae.

A review on the effects of antimicrobials use in cultures of planktonic organisms: a procedure for ecological experiments

To test the sensitivity of the system to ototoxic drug, 7dpf zebrafish larvae were treated with neomycin of 3 different levels of concentration, 0, 0.16, and 1.6 [micro]M, for 24 hours.

Evaluation of the Hair Cell Regeneration in Zebrafish Larvae by Measuring and Quantifying the Startle Responses

Results: Topical ciprofloxacin is more effective in earlier control of congestion and discharge of ear in CSOM; (p value = 0.001 and less than 0.005 respectively) as compared to Neomycin.

COMPARISON BETWEEN THE EFFICACY OF TOPICAL CIPROFLOXACIN WITH NEOMYCIN IN THE MANAGEMENT OF CHRONIC SUPPURATIVE OTITIS MEDIA

Significant differences in mean threshold values were determined using the Wilcoxon signed-rank test for comparison of ABR thresholds before and after neomycin delivery, and comparison of ABR thresholds in control and study groups.

Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results

As neomycin exposure concentrations increased, damaged and missing kinocilia were often observed (Figs.

Aminoglycoside-induced damage in the statocyst of the longfin inshore squid, Doryteuthis pealeii

To confirm the incidence of homologous recombination, PCR amplification of the neomycin gene was carried out.

Inactivation of aprE Gene in Bacillus subtilis 168 by homologus recombination: mohammed rcibbani*, safoura soleymani, hamid mirmohammad sadeghi, narjes soleimani, and fatemeh moazen

The Gentamicin, Neomycin, Co-trimoxazole, Enrofloxacin and Tetracycline were having 66.32, 54.74, 53.68, 45.26 and 32.63 percent of sensitivity respectively (Table- 2).

Drug sensitivity pattern of Escherichia coli isolates from diarrhoeic calves

The plasmid driven by CaMV 35S promoter contains an intron-interrupted [beta]-glucuronidase (gusA) gene and the neomycin phosphotransferase II (nptll) gene conferring resistance to the aminoglycoside antibiotics such as kanamycin, geneticin, and neomycin.

Agrobacterium-mediated transformation of the recalcitrant Vanda Kasem's delight orchid with higher efficiency

Traditionally, neomycin has been produced by submerged fermentation (SmF).

Optimization of medium composition for the production of neomycin by Streptomyces fradiae NCIM 2418 in solid state fermentation

The aminosugars are linked via glycosidic bonds, to the central 2- deoxystreptamine ring either at the 4 and 5 position (4,5-linked type), as in neomycin and paromomycin or at the 4 and 6 position (4,6-linked type), as in kanamycin, gentamicin and tobramycin (Fig.

An Overview of Strategies for Synthetic Modifications of Aminoglycosides

The purpose of this study was providing evidence to the effect of orally administered antibiotic neomycin on the toxicity of vicine.

Effect of the antibiotic neomycin on the toxicity of the glycoside vicine in rats

Neomycin is an aminoglycoside that causes cell death by inhibiting protein synthesis in gram-negative aerobe bacterial strains and some staphylococci.