neomycin


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neomycin

(nē'ōmī`sĭn), broad spectrum antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 effective against both gram positive and gram negative bacteria (see Gram's stainGram's stain,
laboratory staining technique that distinguishes between two groups of bacteria by the identification of differences in the structure of their cell walls. The Gram stain, named after its developer, Danish bacteriologist Christian Gram, has become an important tool
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). It interferes with protein synthesis in sensitive bacterial cells such as species of Proteus and Staphylococcus. Neomycin is mainly used topically in the treatment of skin and mucous membrane infections, wounds, and burns. Although it is also used systemically, it is highly toxic. Neomycin was first isolated in 1949 by the American microbiologist Selman Waksman from a strain of the bacterial species Streptomyces fradiae.

neomycin

[¦nē·ə¦mīs·ən]
(microbiology)
The collective name for several colorless antibiotics produced by a strain of Streptomyces fradiae; the commercial fraction (C23H46N6O13) has a broad spectrum of activity.
References in periodicals archive ?
dysgalactiae have high levels of resistance, especially to oxytetracycline, gentamycin and neomycin.
Susceptibilities to bacitracin and neomycin were tested by the Kirby-Bauer disk diffusion method (Becton Dickinson, Franklin Lakes, NJ, USA).
Can cause anaphylactic reaction to previous mumps vaccine, eggs, or neomycin.
In these experiments, neomycin sulfate was used in the RIA but not in the Ang I-generation mixture used for LC-MS/MS.
The antibiotics used were gentamicin, kanamycin, amikacin and neomycin, and were obtained from Sigma Chemical Co.
with Streptomycin (10 [micro]g), Erythromycin (15 [micro]g), Tetracycline (30 [micro]g), Penicillin (10 [micro]g), Norfloxacin (10 [micro]g), Riphampicin (5 [micro]g), Neomycin (30 [micro]g), Cephalexin (30 [micro]g), Ampicillin (10 [micro]g), Kanamycin (20 [micro]g), Gentamicin (10 [micro]g) were used.
azedarach) was used as a negative control, while neomycin skin ointment (0.
One sample colony of growth on each plate and was emulsified in a nutrient broth and this was used to prepare KB antibiotic sensitivity plates stamped with apramycin, gentamicin, tobramycin, kanamycin, streptomycin, neomycin, and amikacin discs, then incubated for 24 hours at 37[degrees]C.
Directed at new researchers without the benefit of a couple of decades of work in the field, this explains the initial work of Selman Waksman to produce streptomycin, then proceeds to such topics as the biochemistry and genetics of aminoglycoside producers, mechanics of aminoglycoside antibiotic resistance, the development and action of kanamycin and neomycin class antibiotics, NMR structural studies and RNA interaction, structural comparisons between prokaryotic and eukaryotic ribosomal decoding, binding of antibiotics to the aminoacyl-tRNA site of bacterial ribosome, the chemistry and biological relevance of metalloaminoglycosides, adverse effects of aminoglycoside therapy, new efforts at targeting HIV-1 RNA, and novel targets for aminoglycosides.
After induction of anaesthesia, neomycin ophthalmic ointment was applied to his eyes, which were then taped shut.
Medical conditions problematic for MMR vaccination include pregnancy, severe immune system compromise and allergy to neomycin or gelatin.
Scott-A Str was developed with resistance to streptomycin, while OSY-8578 Rf,Nm was made resistant to both rifamycin b and neomycin.