neomycin(redirected from neomycin B)
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neomycin(nē'ōmī`sĭn), broad spectrum antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
..... Click the link for more information. effective against both gram positive and gram negative bacteria (see Gram's stainGram's stain,
laboratory staining technique that distinguishes between two groups of bacteria by the identification of differences in the structure of their cell walls. The Gram stain, named after its developer, Danish bacteriologist Christian Gram, has become an important tool
..... Click the link for more information. ). It interferes with protein synthesis in sensitive bacterial cells such as species of Proteus and Staphylococcus. Neomycin is mainly used topically in the treatment of skin and mucous membrane infections, wounds, and burns. Although it is also used systemically, it is highly toxic. Neomycin was first isolated in 1949 by the American microbiologist Selman Waksman from a strain of the bacterial species Streptomyces fradiae.
The collective name for several colorless antibiotics produced by a strain of Streptomyces fradiae; the commercial fraction (C23H46N6O13) has a broad spectrum of activity.