The clinical information regarding paraneoplastic hypercalcemia warranted the SMARCA4 immunostaining of the tumor (analogous to the SCCOHT) which indeed uncovered loss of this tumor suppressor in the neoplastic cells
. The elevated serum level of PTHrp in this patient is likely responsible for his severe paraneoplastic hypercalcemia and indicates similar pathophysiological mechanism analogous to SCCOHT .
Membrane staining of neoplastic cells
was present in 19 pre-NACT biopsies (35%), with an extent ranging from 1 to 90% (Figures 1(c) and 1(d)).
A cut-off < 10% of positive neoplastic cells
was used to define low expression, 11-50% to define moderate expression, and >50% to define high expression .
Multiple section studied shows tumour composed of neoplastic cells
arranged in sheets, cords, tubules, cribriform, lobules and solid patterns (Figure 3).
Not only extra-CNS tumors, but also tumors arising within the CNS (among which gliomas, ependymomas, medulloblastomas, and germinomas) display relapses and/or multifocal presentations with distant foci and a supposedly intra-CSF pathway of dissemination of neoplastic cells
Cases of disseminated neoplasia in bivalve mollusc species are characterized by the presence of large (2-4 times the diameter of normal hemocytes), neoplastic circulating cells that have a hyperchromatic and often pleomorphic nucleus containing 1 or more prominent nucleoli (Barber 2004), and a high nuclear-tocytoplasmic volume ratio in neoplastic cells
All positive neoplastic cells
exhibited firmly fibrillary diffuse cytoplasmic staining using both TU-20 and TuJ-1 (Fig.).
In conclusion, hypothyroidism, regardless of the functional state of the gonads, resulted in a delayed growth of the ascitic form of Ehrlich tumor as it reduced the liquid volume and did not reduce the number, viability, or diameter of neoplastic cells
They observed neoplastic cells
with large, inclusion-like nucleoli within a myxoid and fibroinflammatory milieu, frequent involvement of the hands and feet, and potential for local recurrence.
Histopathology revealed an unencapsulated, poorly demarcated, highly cellular neoplasm composed of islands and trabeculae of neoplastic cells
embedded in abundant loose fibrovascular stroma which completely obliterated the cortical bone and sinuses of the rostral skull and infiltrated the surrounding muscle and soft tissue.
The presence of CD20 and the absence of CD3 in neoplastic cells
were consistent with a lymphoma of B-cell lineage (CD3 is present in nonneoplastic T-cell lymphocytes).
The neoplastic cells
are large, with round to oval nuclei showing open, vesicular nuclear chromatin and prominent nucleoli (figure 2).