The WT-1 gene product is not present in all
nephroblastomas and may be present in various other tumors.
The bovine
nephroblastoma overexpressed (NOV) gene is positioned near RM192 on bovine chromosome 14 (Lee et al., 2011).
Macroscopically,
nephroblastomas are often very large and heterogeneous, with cystic, necrotic and haemorrhagic areas (Fig.
Such a minimally differentiated status is rare in adulthood tumors but common in some childhood tumors (e.g.,
nephroblastomas, teratomas) that are derived from immature embryonal-like cells (Gisselsson 2007).
By 10am Monday morning they gave us the diagnosis." Medics told Angela and Francis Aiva had a Wilms' tumour - or
nephroblastomas - which affects just 70 UK youngsters each year.