Diabetes Insipidus

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Related to nephrogenic diabetes insipidus: dipsogenic diabetes insipidus, Central diabetes insipidus

diabetes insipidus

[‚dī·ə′bēd·ēz in′sip·ə·dəs]
A form of diabetes due to a disfunction of the hypothalamus.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Diabetes Insipidus


an endocrine disease caused by a low content of the hormone vasopressin in the blood. It is characterized by constant intense thirst and excessive excretion of urine. Diabetes insipidus patients excrete 5 to 50 liters a day of transparent urine with a very low specific gravity (1.005-1.001); the urine is odorless and contains no pathological components, including sugar (unlike the urine of diabetes mellitus patients). As a result of dehydration, diabetes insipidus patients suffer from dryness of the skin and mucous membranes, marked emaciation, general weakness, depression, vertigo and headaches, nausea, and sometimes even vomiting. Diabetes insipidus is caused by injury (owing to infection, tumor, or trauma) to the hypothalamus and pituitary, which form a unified functional system that regulates the excretion of salts and water by the kidneys. A hereditary predisposition to the disease is sometimes noted, and the trait is dominant. Treatment consists of hormonal preparations; chemotherapy is prescribed if the disease is of infectious or inflammatory origin.


Atabek, A. A. Nesakharnyi diabet. Moscow, 1951. (Bibliography.)
Ginetsinskii, A. G. Fiziologicheskie mekhanizmy vodno-solevogo ravnovesiia. Moscow-Leningrad, 1963.
Leaf, A. “Diabetes Insipidus.” In Clinical Endocrinology, vol. 1. New York-London, 1960. Page 73. (Bibliography.)


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
AVPR2 variants and mutations in nephrogenic diabetes insipidus: review and missense mutation significance.
Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment.
Report of 33 novel AVPR2 mutations and analysis of 11 7 families with X-linked nephrogenic diabetes insipidus. J Am Soc Nephrol 2000;11:1044-1054.
Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-CI co-transporter, and epithelial sodium channel.
Changes of rat kidney AQP2 and Na,K ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus. Nephron Exp Nephrol 2004; 97: e1-16.
Functional characterization of the molecular defects causing nephrogenic diabetes insipidus in eight families.
(32.) Deen PM, Knoers NV Vassopressin type-2 receptor and aquaporin-2 water channel mutants in nephrogenic diabetes insipidus. Amer.
Brief report: A mutation in the vassopression V2-receptor gene in a kindred with X-linked nephrogenic diabetes insipidus. N Eng.
Bockenhauer, "Genetic forms of nephrogenic diabetes insipidus (NDI): vasopressin receptor defect (X-linked) and aquaporin defect (autosomal recessive and dominant)," Best Practice & Research Clinical Endocrinology & Metabolism, vol.
Monnens, "Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus," Journal of the American Society of Nephrology, vol.
Dattani et al., "Secondary nephrogenic diabetes insipidus as a complication of inherited renal diseases," Nephron Physiology, vol.
Bichet, "Inherited secondary nephrogenic diabetes insipidus: concentrating on humans," American Journal of Physiology-Renal Physiology, vol.