Diabetes Insipidus

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Related to nephrogenic diabetes insipidus: dipsogenic diabetes insipidus, Central diabetes insipidus

diabetes insipidus

[‚dī·ə′bēd·ēz in′sip·ə·dəs]
A form of diabetes due to a disfunction of the hypothalamus.

Diabetes Insipidus


an endocrine disease caused by a low content of the hormone vasopressin in the blood. It is characterized by constant intense thirst and excessive excretion of urine. Diabetes insipidus patients excrete 5 to 50 liters a day of transparent urine with a very low specific gravity (1.005-1.001); the urine is odorless and contains no pathological components, including sugar (unlike the urine of diabetes mellitus patients). As a result of dehydration, diabetes insipidus patients suffer from dryness of the skin and mucous membranes, marked emaciation, general weakness, depression, vertigo and headaches, nausea, and sometimes even vomiting. Diabetes insipidus is caused by injury (owing to infection, tumor, or trauma) to the hypothalamus and pituitary, which form a unified functional system that regulates the excretion of salts and water by the kidneys. A hereditary predisposition to the disease is sometimes noted, and the trait is dominant. Treatment consists of hormonal preparations; chemotherapy is prescribed if the disease is of infectious or inflammatory origin.


Atabek, A. A. Nesakharnyi diabet. Moscow, 1951. (Bibliography.)
Ginetsinskii, A. G. Fiziologicheskie mekhanizmy vodno-solevogo ravnovesiia. Moscow-Leningrad, 1963.
Leaf, A. “Diabetes Insipidus.” In Clinical Endocrinology, vol. 1. New York-London, 1960. Page 73. (Bibliography.)


References in periodicals archive ?
Identification and characterization of aquaporin2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response.
Disordered water channel expression and distribution in acquired nephrogenic diabetes insipidus.
For example, nephrogenic diabetes insipidus can be caused by either deficient or defective AQP2 or a malfunction in response to ADH-mediated control of AQP2 activity.
Watson, and his wife, Jaleh, were searching for a better way to administer liquid medicine to their son, Brandon, diagnosed with Nephrogenic Diabetes Insipidus, a rare kidney disorder, shortly after birth.