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Related to Nephrosclerosis: malignant nephrosclerosis


Sclerosis of the renal arteries and arterioles.



a condition of kidneys arising during the final stage of hypertensive disease and accompanied by a proliferation of connective tissue and the onset of uremia. Nephrosclerosis arises less frequently in such diseases as atherosclerosis of the principal vessels of the kidneys, pyelonephritis, tuberculosis of the kidneys, diffuse glomerulonephritis, and nephrolithiasis.

When occurring in conjunction with hypertension, nephrosclerosis is accompanied by hyalinosis and necrosis of the small arteries of the kidneys. In pronounced cases of nephrosclerosis, the kidneys become smaller and acquire a granular surface. Occasionally, the surface appears nodular. In cases of malignant hypertension, early diagnosis of nephrosclerosis is possible only through a biopsy of the kidney; tests of kidney function and X-ray and radioisotopic tracer analyses are also carried out.

Treatment involves a salt-free diet, agents that decrease arterial pressure, and antibacterial measures in cases complicated by infection. Surgical treatment is recommended in some instances of renal injury.


Miasnikov, A. L. Gipertonicheskaia bolezn’i ateroskleroz. Moscow, 1965.
Osnovy nefrologii, vol. 2. Edited by E. M. Tareev. Moscow, 1972.
Pochki. Edited by F. K. Mostofi and D. E. Smith. Moscow, 1972. (Translated from English.)


References in periodicals archive ?
0 Cause of ESRD, n (%) Glomerulonephritis 2 (10) Diabetic nephropathy 8 (40) Nephrosclerosis 2 (10) Other or unknown 8 (40) Patients with DM, n (%) 11 (55) Patients with CHF, n (%) 5 (25) Patients on ACEI or ARB, n (%) 13 (65) Mean daily dose furosemide mean [range], mg 171.
that although BP reduction to levels below current guidelines for cardiovascular risk reduction are achievable, our results do not support additional reduction as a strategy to prevent progression of hypertensive nephrosclerosis.
Researchers discovered that the percentage of donors with nephrosclerosis ranged from 2.
Rule is working with an international team to develop a new test for nephrosclerosis.
The arterial nephrosclerosis is characterized by vascular changes, including hyaninosis involving predominantly arterioles (Figure 1, C) and intimal fibrous thickening involving arteries regardless of size (Figure 1, B).
Comparison of cross-sectional renal function measurements in African-Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate.
Histologic examination of the kidney showed mild nephrosclerosis with no evidence of infection.
Underlying kidney diseases were as follows: diabetic nephropathy (n = 31), chronic glomerulonephritis (n = 52), nephrosclerosis (n = 8), polycystic kidney disease (n = 3), other diseases (n = 5), and unknown diseases (n = 14).
Using autopsy specimens, we studied the existence of any possible correlation of elastosis with age, prostatic atrophy, local arteriosclerosis, histologic (or incidentally found) carcinoma, high-grade prostatic intraepithelial neoplasia, benign or malignant nephrosclerosis, generalized atherosclerosis, nodular prostatic hyperplasia, and acute inflammation.
Primary diagnosis was chronic interstitial nephropathy (n = 4), diabetic glomerulopathy (n = 3), polycystic kidney disease (n = 3), nephrosclerosis (n = 3), focal segmental glomerulosclerosis (n = 2), IgA nephropathy (n = 3), amyloidosis (n = 2), vascular nephropathy (n = 1), Goodpasture syndrome (n = 1), systemic lupus erythematosus (n = 1), uric acid nephropathy (n = 1), membranous glomerulonephritis (n = 1), mesangiocapillary glomerulonephritis (n = 1), and unknown (n = 4).
The renal diagnoses were polycystic kidney disease (n = 2), diabetic nephropathy (n = 2), glomerulonephritis (n = 2), nephrosclerosis (n = 1), bilateral nephrectomy attributable to cancer (n = 1), and light chain nephropathy (n = 1).
Renal failure was caused by diabetes in 11 (46%) patients and by chronic glomerulonephritis (n = 3), polycystic kidney disease (n = 1), hypertensive nephrosclerosis (n = 6), focal glomerulosclerosis (n = 2), and poststreptococcal glomerulonephritis (n = 1).