nephrosis


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Related to nephrosis: hydronephrosis

nephrosis

(nəfrō`səs), kidney disease characterized by lesions of the epithelial lining of the renal tubules, resulting in marked disturbance in the filtration function and the consequent appearance of large amounts of protein (albumin) in the urine (see urinary systemurinary system,
group of organs of the body concerned with excretion of urine, that is, water and the waste products of metabolism. In humans, the kidneys are two small organs situated near the vertebral column at the small of the back, the left lying somewhat higher than the
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). The nephrotic syndrome can result from a number of conditions including streptococcal infection in children leading to chronic glomerulonephritis, reaction to toxins, diabetes, collagen disease, and other end-stage kidney diseases. The major symptom is massive edema. Corticosteroid therapy has been successful in treating certain forms of the disease.

Nephrosis

 

an obsolete term for the nephrotic syndrome. The term was used to designate degenerative changes in the renal tubules accompanied by a massive excretion of protein in the urine, by a decrease in the protein content and an increase in the fat content of the blood, by edema, and by other symptoms.

Lipoid and amyloid nephroses were once classified as distinct diseases. Detailed histological studies of the kidneys, especially those studies that used the electron microscope and other research methods, have established that the glomeruli are affected in nephrosis as well as the tubules. Thus, there is no strict morphological difference between nephritis and nephrosis. Furthermore, clinical observations show that a disease that begins as lipoid nephrosis often acquires features of nephritis and, conversely, that glomerulonephritis develops into lipoid nephrosis.

nephrosis

[nə′frō·səs]
(pathology)
Degenerative or retrogressive renal lesions, distinct from inflammation (nephritis) or vascular involvement (nephrosclerosis), especially as applied to tubular lesions (tubular nephritis). Also known as nephrodystrophy; nephropathy.
References in periodicals archive ?
Retinoids as a potential treatment for experimental puromycin-induced nephrosis.
Mortality from nephritis and nephrosis in the fibreglass manufacturing industry.
Immunosuppressant pharmacodynamics on lymphocytes from healthy subjects and patients with chronic renal failure, nephrosis and psoriasis: possible implications for individual therapeutic efficacy.
IVIG products have been associated with renal dysfunction, acute renal failure, osmotic nephrosis, and death.
A 49-year-old Japanese man had nephrosis at the age of 25 years and had been a long-term, heavy drinker From the age of 39 years, he had been undergoing dialysis for chronic renal failure, at which time he was diagnosed as having diabetes mellitus and liver cirrhosis.
Non-neoplastic effects include reduced body weight and increased relative spleen weight, hepatocellular degeneration, proliferation of cells lining the liver sinusoids, degenerative alteration in the testis, tubular nephrosis, and focal degeneration of the myocardium in rats (38,39).
Regulation of apolipoprotein gene expression and plasma high density lipoprotein composition in experimental nephrosis.
Congenital abnormalities of amino acid metabolism, severe dyslipidemia, non-corrected metabolism disorders, severe sepsis, severe liver disease, blood coagulation disorders, thrombophlebitis, acute myocardial infarction, lipoid nephrosis, acute pancreatitis associated with hyperlipidemia, severe hyperglycemia.
Studies on ochronosis: a report of a case with death from ochronotic nephrosis.
Thus, the kidneys, after many injections of the protein, showed the characteristic macroscopic picture of the third stage of the amyloid nephrosis.
Immunoglobulin Intravenous (Human) products have been reported to be associated with renal dysfunction, acute renal failure, osmotic nephrosis, and death.
Cleviprex is contraindicated in patients with allergies to soybeans, soy products, eggs, or egg products; defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis, or acute pancreatitis if it is accompanied by hyperlipidemia; and in patients with severe aortic stenosis.