Immunolocalization of nerve growth factor
(NGF) and its receptors (TrkA and p75LNGFR) in the reproductive organs of Shiba goats.
Beta adrenergic inhibition of capsaicin-induced, NK1 receptor-mediated nerve growth factor
biosynthesis in rat skin.
The report includes a compilation of current active projects in research and development of nerve growth factor
(NGF) targeting small molecules, antibodies, cells and DNA.
The drug candidate, CXB909, is a small molecule, orally active agent that enhances the effects of nerve growth factor
involved surgical implantation of cells producing nerve growth factor
(NGF), a natural brain survival molecule.
These studies demonstrated that approximately 80% of the cholinergic neurons in the basal forebrains of both young and aged primates normally destroyed by lesion in a model of Alzheimer's disease were preserved by the delivery of human nerve growth factor
(hNGF) secreted from the Company's CRIB(TM) devices.
Now, a new study shows that the body's concentration of nerve growth factor
(NGF), a protein that helps neurons survive, increases under stress.
Senior Director of Research at CytoTherapeutics, reported in the March edition of "Proceedings of the Natural Academy of the Sciences of the United States of America" (PNAS) stable, long-term delivery of therapeutically significant quantities of human Nerve Growth Factor
(hNGF) from the Company's cell-containing devices implanted within the brain.
PRX-03140 was further found to increase levels of brain nerve growth factor
, a protein that regulates nerve cell development, repair, and regeneration, and brain-derived neurotrophic factor, a protein that promotes cell growth and survival.
The first application under the agreement will be the use of Nerve Growth Factor
(NGF) for the treatment of Alzheimer's disease, using CytoTherapeutics' encapsulated cell implants for the site-specific, continuous delivery of NGF.
Rinat will determine whether RN624, a first-in-class monoclonal antibody that inhibits Nerve Growth Factor
, meets the trial's primary efficacy objective of pain and functionality improvements in osteoarthritis.
Still others die when denied various types of life-support molecules, such as nerve growth factor