Many clinical studies have found that maternal supplementation with vitamins including folic acid, before conception and during the first trimester of pregnancy, significantly reduces the risk of neural tube defects
.(5-12) It appears that folic acid is the most important of these vitamins.
Yayla, "Jarcho-Levin syndrome presenting as neural tube defect
: report of four cases and pitfalls of diagnosis," Fetal Diagnosis and Therapy, vol.
Neural tube defects
and associated anomalies in South Carolina.
A question that is still not resolved is whether folic acid can prevent other malformations, not just neural tube defects
. There is some evidence that folic acid supplementation may also reduce the risk of cardiovascular defects and oral clefts.
Neural tube defects
: prevalence, etiology and prevention.
Through this research it was also established that the literate women had more knowledge about the importance of folic acid and were also having good practice as compared to illiterate women (pgreater than 0.009 with 95% CL).It is widely accepted that pre-conceptional supplementation with folic acid can prevent a significant proportion of neural tube defects
(NTDs).134 A literature search was conducted to identify studies that included assessment of folicacid knowledge and use in U.K.
Although the prevalence of neural tube defect
is decreasing worldwide especially in England and America with peak at 1930 and 1960 and downward trend since 1970.
Genetics of neural tube defects
. MRDD 1998;4(4):269-281.
Of these, only 27.6% knew that folate was something important in the prevention of neural tube defects
. Overall, 20.12% of the total women took folic acid during periconceptional period.
A neural pediatric specialist, who declined to be identified, said he was seeing on average three or four newborns with neural tube defects
a week in Fallujah and its surrounding areas, a region with a population of about 675,000 people.Aa
Women who have a child with spina bifida, have spina bifida themselves, or have already had a pregnancy affected by any neural tube defect
are at greater risk of having a child affected by spina bifida or another neural tube defect
Supplementing a woman's diet with folic acid reduces her chances of having a child with a neural tube defect
. This has been shown in experimental and observational studies and for the last 15 years all women have been encouraged to take folate periconceptually.