neural tube defects


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neural tube defects

[‚nür·əl ′tüb ‚dē‚feks]
(medicine)
Congenital defects resulting from the incomplete closure of the neural tube during embryogenesis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
"There is substantial evidence that increased intake of folic acid reduces the risk of neural tube defects occurring in pregnancy...
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
Based on the results reported before, the PONTI (Prevention of Neural Tube Defects by Inositol) study was designed as a pilot study, aiming to demonstrate the feasibility of a randomized clinical trial (RCT) to evaluate the effectiveness of inositol plus folic acid in preventing a greater number of NTDs as compared to folic acid alone, according to the previous experimental hypothesis.
More recent efforts by our group ("Spina Bifida: A 10-Year Retrospective Study at University of Malaya Medical Centre, Malaysia," manuscript in submission), however, have found that the lower rate of NTDs may not be completely representative as in our hospital alone from the years 2003 to 2012 we have had over 10 cases of neural tube defects per year (spina bifida and anencephaly).
One of the early studies showing the promise of folic acid beyond neural tube defects was published in 1996.
A question that is still not resolved is whether folic acid can prevent other malformations, not just neural tube defects. There is some evidence that folic acid supplementation may also reduce the risk of cardiovascular defects and oral clefts.
OBJECTIVE: To determine prevalence of NTD in tertiary care center (KIMS Karad) from 1st July 2012 to 30th June 2013.To determine effectiveness of prenatal screening for neural tube defects.
Main birth defects are neural tube defects, spinal disc herniation, esophageal atresia, gastroschisis (infant's intestines stick out of the body through a defect on one side of the umbilical cord), and several others.
'There's strong evidence that taking the supplement before and during pregnancy reduces the incidence of neural tube defects," says gynecologist Ellen Wilson.
Folic acid has been proven to prevent neural tube defects in the newborn (Harvey & Ricciotti, 2014), a condition that affects nearly 3000 pregnancies in the United States each year (Centers for Disease Control and Prevention {CDC}, 2008).