neuraminidase


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Related to neuraminidase: sialic acid, Neuraminidase inhibitor

neuraminidase

[‚nu̇r·ə′min·ə‚dās]
(microbiology)
A bacterial enzyme that acts to split salic acid from neuraminic acid glycosides.
References in periodicals archive ?
Patients with flulike illness who present outside the context of an influenza outbreak and are considered to be at low risk for influenza-related complications should be tested to confirm the diagnosis before starting antiviral treatment with a neuraminidase inhibitor, according to another decisional analysis study.
Our findings suggest that neuraminidase of human influenza A(H7N9) virus might have originated from influenza A(H11N9) viruses that circulated in eastern China, although limited information about influenza A virus N9 subtypes circulating in wild birds in this region represents a major challenge to identifying the donor of influenza A(H7N9) virus neuraminidase.
FIGURE 37 U S MARKET FOR NEURAMINIDASE INHIBITORS, 2009-
Indeed, the number of patients who needed to be treated (NNT) with a neuraminidase inhibitor to prevent one additional case of acute otitis media was 18.
was not involved in these studies but has done studies of Tamiflu and Relenza (zanamivir), the other available neuraminidase inhibitor, which is in a dry powder formulation that is inhaled.
50]s (concentration of neuraminidase inhibitor required to reduce enzyme activity by 50%) with all 4 NAIs, similar to results for the drug-sensitive seasonal influenza A viruses used as controls (Table 1).
With the aid of the neuraminidase protein, the influenza virus is free to exit from the infected cell, enabling it to infect new neighbor cells and spread in the respiratory system.
The addition reflects postmarketing reports of delirium and abnormal behavior in patients with influenza taking neuraminidase inhibitors, including zanamivir (Relenza, Glaxo-SmithKline).
This strain harbored mutations in the gene for neuraminidase, the enzyme targeted by the antiviral drugs.
In conjunction with Sankyo Co Ltd of Japan, Biota is also developing a second generation of flu antivirals called LANI (longacting neuraminidase inhibitors) for the treatment and prevention of influenza.
Laninamivir is an influenza antiviral, known as a long acting neuraminidase inhibitor (LANI) and a unique treatment for influenza.