Karsen et al reported that mean CSF ADA levels in tuberculous were 28.34 +- 14.83 IU/L, 8.71 +- 5.83 IU/L in neurobrucellosis
, 6.18 +- 2.54 IU/L in purulent meningitis and 3.43 +- 3.48 U/L in aseptic meningitis, when cut off value of ADA levels were kept at 12.357.
(13.) McLean DR, Russell N, Khan MY Neurobrucellosis
: Clinical and therapeutic features.
We report a case of neurobrucellosis
mimicking the symptoms, laboratory data, and the pathologic findings that can be seen in systemic lupus erythematosus (SLE), thus demonstrating the diagnostic challenges of such a heterogeneous disease.
The percentage frequency of final diagnosis in this group of patients was as follows: SAE (n = 61, 27%), bacterial meningitis (n = 27, 11.9%), encephalitis or meningoencephalitis of undetermined etiology (n = 27, 11.9%), neurotuberculosis (n = 20, 8.8%), toxic encephalopathy (n = 19, 8.4%), unidentified etiology (n = 16, 7.1%), herpes simplex encephalitis (n = 15, 6.6%), metabolic encephalopathy (n = 13, 5.8%), parameningeal infections/brain abscesses (n = 5, 4.2%), meningitis/encephalitis with other etiologies (n = 9, 4%), neurobrucellosis
(n = 2, 2.9%), Varicella Zoster Virus encephalitis (n = 5, 2.5%), viral meningitis (n = 3, 1.3%), and others (n = 6, 2.7%).
is a rare complication of brucellosis, a common zoonosis with multisystem involvement.
usually presents as meningoencephalitis.
Infected people show the symptoms of fever, arthralgia, myalgia, back pain, hepatomegaly, splenomegaly, endocarditis, neurobrucellosis
, epididymitis and orchitis (Dean et al., 2012; Godfroid et al., 2011; Olsen and Palmer, 2014).
: unexpected answer from metagenomic next-generation sequencing.
: unexpected answer from metagenomic next-generation sequencing [published online ahead of print January 6, 2017].
Brucellosis involving the central nervous system (CNS) is termed neurobrucellosis
. The most common complications are meningitis and meningoencephalitis.
Nine years later, neurobrucellosis
was first reported by Matthew Hughes .
is a rare complication in childhood which can be detected in 2-7 percent of cases.