We present two cases of neurobrucellosis
with widely varying clinical involvement from a tertiary center in Pakistan.
usually presents as meningoencephalitis.
Infected people show the symptoms of fever, arthralgia, myalgia, back pain, hepatomegaly, splenomegaly, endocarditis, neurobrucellosis
, epididymitis and orchitis (Dean et al.
is a rare complication in childhood which can be detected in 2-7 percent of cases.
Presence of viable bacteria is sufficient to detect brucellosis, yet the lack of a positive culture from clinical specimens especially in chronic cases and neurobrucellosis
does not rule out the disease since a very low number of bacteria may be present in an infected person (Araj et al.
Roldan-Montaud A, Jimenez-Jimenez FJ, Zancada F, Molina-Arjona JA, Fernandez Ballesteros A, GutierrezVivas A (1991) Neurobrucellosis
(NB) often is underdiagnosed, which is partly because of unawareness about the disease among the treating physicians.
2) Four human cases of marine mammal brucellosis have been reported since 2001 with two cases in males from coastal Peru treated in the United States for neurobrucellosis
with granulomatous intracerebral lesions; one patient in New Zealand with spinal osteomyelitis; and one veterinary laboratory worker with a mild form of brucellosis.
He was prescribed oral rifampin, doxycycline and ceftriaxone combination therapy for 1 year with the suspicion of neurobrucellosis
A 3-year-old girl, who was admitted to hospital with convulsion and joint complaints, was evaluated in terms of neurobrucellosis
The clinical presentations of human brucellosis range from non-specific and constitutional symptoms, like prolonged fever, anorexia, or fatigue to local organ involvement, such as arthritis and neurobrucellosis
Up to 5-10% of Brucellosis cases manifest with neurobrucellosis
and course with various forms such as meningocephalitis, cerebellitis, acute meningitis, myelopathy, radiculopathy neuropsychiatric syndromes and cranial neuropathy.