Neurofibril

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neurofibril

[¦nu̇r·ō′fī·brəl]
(neuroscience)
A fibril of a neuron, usually extending from the processes and traversing the cell body.

Neurofibril

 

a microscopic filament that is found upon treatment of nerve cells—neurons—and the longest outgrowths of the nerve cells—axons—with silver salts and other reagents.

In the late 19th and early 20th centuries, neurofibrils were ascribed the function of conducting nerve impulses. This view proved to be erroneous when it was found that nerve impulses are conducted by the external membrane of the neuron. Electron microscopy revealed two kinds of longitudinal neurofibrils in the outgrowths of neurons: neurotubules and neurofilaments. Neurotubules are from 20 to 25 nm in diameter and are formed from the protein tubulin; they are believed to transport substances along the axon. The threadlike neurofilaments are formed from a protein similar to the muscle protein actin. Neurofilaments are especially numerous in the movable terminal portions of growing axons.

References in periodicals archive ?
7] Recently, the TauRx Company reported that the phase III trial of their new drug LMTM (an amethylthionine chloride derivation which was thought to be able to inhibit the generation of neurofibrillary tangles through Tau) was unsuccessful.
Amyloid plaques and neurofibrillary tangles in the brain are the principal hallmarks of AD, and their formation is associated with the degradation of neurons (nerve cells) in the brain, leading to symptoms of the disease.
Socorro Martinez, and the US National Institute on Aging website, Alzheimer's disease (AD) results when an abnormal buildup of protein in the brain forms neurofibrillary tangles and amyloid plaques, which appear like clumps in the brain.
The project teams will evaluate drugs targeting tau neurofibrillary tangles in the brain that, along with amyloid plaques, are characteristic of the disease.
discuss how oxidative stress is related to AD progression and to the formation of A[beta] plaques and tau neurofibrillary tangles.
According to the companies, C2N-8E12 is a humanized antibody targeting the tau protein found in neurofibrillary tangles in the brain of patients with tauopathies such as PSP and Alzheimer's disease (AD).
The researchers found that, in addition to a thicker and larger cingulate cortex, SuperAgers had 90% fewer neurofibrillary tangles of the type observed in Alzheimer's disease and increased density of von Economo neurons related to social intelligence.
Compared with similarly aged people, as well as younger volunteers, SuperAgers have a thicker, larger region of the cortex in the brain, significantly fewer neurofibrillary tangles (a marker of Alzheimer's), and a huge supply of a neuron, called von economo, which has been linked to higher social intelligence.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain.