Finally, it appears that once A[Beta] is deposited in the neuropil, it triggers a cascade of events that include microglial activation, neuritic abnormalities, and neurofibrillary
TANGLE--an accumulation of abnormal fibers in the nerve cells in the cerebral cortex.
"Together, the sex difference in the association between APOE and CSF measures of tau and the lack of a sex difference in the association with neurofibrillary
tangles at autopsy suggest that APOE may modulate risk for neurodegeneration in a sex-specific manner, particularly in the presence of amyloidosis," the authors write.
Amyloid plaques and neurofibrillary
tangles in the brain are the principal hallmarks of AD, and their formation is associated with the degradation of neurons (nerve cells) in the brain, leading to symptoms of the disease.
tangles, which are composed of abnormally phosphorylated tau protein aggregates, appear as parallel, thickened fibrils that extend toward the apical dendrite of pyramidal neurons.
The final study examined the effect of an active tau immunotherapy on mice engineered to develop neurofibrillary
One particular group of heterogeneous dementias and movement disorders is characterized by intracellular accumulations of abnormal filaments called neurofibrillary
tangles (NFT), formed by the microtubule-associated protein tau.
Today, he says, it's most likely that there are two primary causes of dementia: an Alzheimer's disease type "pathology," represented by the neurofibrillary
tangles and senile plaques of the disease, and vascular dementia, resulting from significant changes in blood vessels in the brain.
It cleared out that protein and another one that makes up the cell-killing "neurofibrillary
The brains of AD patients have clumps of fibrous proteins called neurofibrillary
Brain tissue samples of Alzheimer's victims reveal extensive neuronal cell death, as well as two abnormal pathological structures known as "neurofibrillary
tangles" and "amyloid plaques."
From pathologic reviews, hallmarks of AD include extracellular plaques and intracellular neurofibrillary
tangles in parts of the brain involved with cognition and memory.