neurofilament


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neurofilament

[‚nu̇·rō′fil·ə·mənt]
(physiology)
A type of intermediate filament, composed of three polypeptides (NF-L, NF-M, and NF-H), that helps support and strengthen the axons of nerve cells.
References in periodicals archive ?
1997; Lee and Cleveland 1996), so it is likely that changes in glial markers (GFAP, MBP) interact with those for development of the neuronal neurofilament proteins.
A number of immunological studies have shown regional phylogenetic conservation of neurofilament proteins (Chiu et al.
Guidelines for the diagnostic differentiation of schwannoma (modified from Buric et at (12)) Markers Result Encapsulation + Pathological formation Antoni A and Antoni B areas with Verocay bodies Cell differentiation High Source of internal bleeding + Tumor necrosis - Protein S-100 + Leu-7 + Glial fibrillary acidic - protein (GFAP) Synaptophysin - Neurofilament - Vimentin +
The results of immune staining for S-100 and neurofilament showed various outcomes.
In animals, the ganglion cells of ganglioneuroma and ganglioneuroblastoma are strongly immunoreactive for neurofilament (KOESTNER & HIGGINS, 2002).
Changes in neurofilament expression have been found during development in response to neurotoxins both in vitro and in vivo.
Differential expression of two neuronal intermediate-filament proteins, peripherin and the low molecular mass neurofilament protein (NF-L), during the development of rat.
The immunohistochemical stains performed were Neuron Specific Enolase (NSE) (Dako,1:400), Chromogranin A (Dako, 1:5000), CD56 (NovoCas- tra,1:50), Neurofilament (Dako,1:400), S-100 (Dako, 1:1000), Synaptophysin (Biogenex, 1:400), Vimentin (Vim 3B4 Dako, 1:100), CD 99 (mic-2 12E7 Dako, Pre-diluted), Cytokeratin (clone AE1/AE3 Dako 1:50), Epithelial Membrane Antigen (EMA) (E29, Dako, 1:50), Cytokeratin 7 (OV-TL 12/30, Dako, 1:100), CD117 (c-kit - Dako, 1:100), Desmin (D33, Dako, 1:150), Cytokeratin CAM 5.
Researchers also reported that valproic acid reduced mRNA and protein levels of neurofilament 160; a possible mechanistic explanation involves inhibition of neurite outgrowth that leads to gait disturbance.
Oxidative stress can cause damage in neurons via nerve lipid peroxidation, the breakdown of mitochondrial DNA and inhibition of the respiratory chain, and the cross-linking of the neurofilament protein (75).
Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS).
High levels of neurofilament light chain protein (NFL) together with low levels of amyloid-beta 1-42 distinguished progressive supranuclear palsy from PD at baseline as well as 1 year later, after patients had been receiving dopaminergic therapy for months.