8-10) In all of these cases, the patients were given a
neuroleptic medication, which they had not been accustomed to, for the treatment of postoperative nausea or agitation, and which subsequently triggered NMS.
Neuroleptic malignant syndrome (NMS) rare but life-threatening side effect of antipsychotic medications.
Neuroleptic malignant syndrome (NMS) is an uncommon but potentially fatal idiosyncratic reaction to
neuroleptics, characterized by a distinctive clinical syndrome of mental status change, rigidity, fever, and dysautonomia (1).
This case is important because it is the first time Olanzapine induced fever has been described in the absence of
neuroleptic malignant syndrome.
Arslankoylu AE, Kutuk MO, Okuyaz C, Toros E
Neuroleptic malignant syndrome due to risperidone misdiagnosed as status epilepticus.
It is a global rating scale and records the occurrence of Tardive Dyskinesia (TD) in patients receiving
neuroleptic medications and to follow the severity of a patient's TD over time.
DSM-5 includes the presence of catatonic symptoms consecutive to the administration of antipsychotics within
neuroleptic malignant syndrome or medication-induced parkinsonism (by the gravity of symptoms).
However, more research is needed towards better understanding the role of somatic factors that might trigger the psychoses and the efficacy (acute phase and prophylaxis) of
neuroleptics agents, benzodiazepines, anticonvulsive agents and electroconvulsive therapy (3).
Treatment of
neuroleptic induced akathisia with the 5-HT2 antagonist ritanserin.
Lithium, particularly in high doses, is also associated with neurotoxicity [7,8] so it is reasonable to suggest that individuals concurrently taking lithium and
neuroleptic medications--a substantial minority of individuals with manic phase bipolar disorder--are at greater risk of developing NMS than those taking antipsychotic medications without lithium.
Neuroleptic malignant syndrome (NMS) is a rare, but potentially life-threatening adverse reaction to antipsychotic drugs and other dopamine-modulating agents.
Tardive syndrome incidence is about 20% in patients taking
Neuroleptic, older female are at greater risk.
