neuromuscular junction


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neuromuscular junction

[¦nu̇r·ō′məs·kyə·lər ′jəŋk·shən]
(anatomy)
References in periodicals archive ?
A possible mechanism by which NMO-Ig can exacerbate MG can be by interacting with the muscle AQP4, clustering more FC receptors and increasing the local neuromuscular junction pathology.
Coffield, "Molecular targets of botulinum toxin at the mammalian neuromuscular junction," Movement Disorders, vol.
Cho et al., "Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction," Molecular and Cellular Neuroscience, vol.
Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junctions. It is characterized by decrease in the number of available nicotinic acetylcholine receptors at postsynaptic membrane due to presence of pathogenic autoantibodies [1, 2].
Diagnosis can be made with the presence of antibodies at the neuromuscular junction. Presence of antibodies to the nicotinic acetylcholine receptor (AChR) is most common, with a positive result in 80% of adults with generalized Myasthenia Gravis [1].
"The neuromuscular junction is involved in a lot of very incapacitating, sometimes brutal and fatal disorders, for which a lot has yet to be discovered," says Sebastien Uzel, who led the work as a graduate student in MIT's Department of Mechanical Engineering.
MG is an autoimmune disease of the neuromuscular junction. When medical management fails, VATS-ET is well established for the treatment of MG.
Our primary objective was to measure the incidence of residual paralysis in the OR prior to extubation and at the time of admission to the recovery unit, in addition to evaluating the severity of the residual paralysis in association with clinical signs measurements for the recovery of the neuromuscular junction. In every case any residual paralysis-related complications were mentioned, in addition to the pharmacological reversal, including the need to admit the patient to the ICU.
BTX blocks the release of acetylcholine from nerve endings at the neuromuscular junction, and selectively affects motor nerves without affecting sensory nerves (Bhakta et al, 1996).
The lesion could be in the corticospinal tract if it is an upper motor neuron lesion, or it could be tied to more peripheral damage (at the spinal nerve level or at the neuromuscular junction, for example).

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