Neuropathy

(redirected from Neuropathic pain)
Also found in: Dictionary, Thesaurus, Medical.

neuropathy

[nu̇′räp·ə·thē]
(medicine)
Any disease affecting neurons.

Neuropathy

 

a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.

REFERENCES

Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.

L. M. SHMAONOVA

References in periodicals archive ?
The company's novel lead candidate NB-01 is a potential treatment for diabetic neuropathic pain. Its second drug compound focuses on Alzheimer's disease currently ready for an IND and Phase IIa trial.
Applied to the area of pain, the capsaicin reduces the spontaneous activity and consequently reduces the neuropathic pain intensity.
(10) The ability of THC or CBD to act on C[B.sub.2] receptors blocks activation of the brain cells known as microglia, thereby preventing the development of neuropathic pain. (27)
Neuropathic pain is usually managed with a variety of pharmacological and non-pharmacological therapies12 Among non-pharmacological treatments Transcranial Electrical Stimulation (TES), acupuncture, massage therapy and Transcutaneous Electrical Nerve Stimulation (TENS) are some of the frequently used modalities/ techniques for relieving neuropathic pain in SCI patients.
In brief, the CFA (oil:saline, 1:1; Sigma) was subcutaneously injected into three unilateral skin sites (30 [micro]L/site; Figure 1) on the face to induce trigeminal neuropathic pain as previously described (17,18).
The PWMT and PWTL in the 12 mg/kg stavudine and 2 mg/kg rapamycin groups were significantly decreased on day 7, 14, 21, 28, 35, and 42 after drug administration compared with those in the control group, and the PWMT and PWTL were the lowest on the 42nd day, indicating that oral administration of stavudine caused peripheral neuropathic pain.
In the present study, the prevalence of neuropathic pain was found to be higher among pregnant women with LPP.
The mainstay of most treatments for neuropathic pain includes utilization of gabapentin and pregabalin, which decrease cellular excitability through hyperpolarization [12, 13].
Neuropathic pain in the area of the GFN as a complication after laparoscopic donor nephrectomy is rarely reported [3].
One mechanism that has been supposed to modulate neuropathic pain is the transient receptor potential (TRP) channel which detects noxious, irritant, and inflammatory stimuli [6].
The consortium will investigate neuron-glia interactions aiming to develop authentic cellular (co-culture) assaid to discover improved treatments of neuropathic pain using neuronal and glial cell types derived from human induced pluripotent stem cells (iPSC), and their co-cultures.