And they concluded that patients who develop a high fever in the first 36 hours after treatment are at increased risk for severe
neurotoxicity.
From this case report, we highlight the excellent response of methylprednisolone on high-dose cytarabine cerebellar toxicity that suggests an immune-mediated mechanism of
neurotoxicity.
So far, several mechanisms of the cisplatin-induced
neurotoxicity have been proposed.
In Groups PX, GDX, and PX + GDX, cell apoptosis was observed and the number of apoptotic cells was significantly higher than that of Group A, indicating that PX or GDX could induce a significant increase of apoptosis in the OB, which means that apoptosis is involved in
neurotoxicity induced by PX and GDX.
Associated hazards include: acute toxicity (acute lethality at high concentrations only), blood toxicity, immunotoxicity, cardiovascular toxicity, liver toxicity, kidney toxicity, reproductive toxicity, developmental toxicity, and
neurotoxicity.
Tolerance can happen with either, but tolerance is not
neurotoxicity as it can be reversed by taking breaks.
Here are 10 agents with neuroprotective effects supported by published data that can be considered as add-on to the standard treatments in an effort to mitigate
neurotoxicity and protect the brain from the destructive processes that accompany acute episodes of psychosis, mania, and depression.
After the exclusion of traumatic causes, nontraumatic
neurotoxicity caused by the accumulative baclofen was highly suspected due to the strong history of taking renally-eliminated baclofen, which may cause neurological symptoms in advanced CKD.
Assessment of Bisphenol A (BPA)
neurotoxicity in vitro with mouse embryonic stem cells," Journal of Environmental Sciences, 2015 DOI: 10.
Due to high antioxidant activity the methanol fraction was used to rescue the oxidative stress induced
neurotoxicity in zebrafish embryos.
Since its approval by the Food and Drug Administration in 1970 as treatment for bipolar disorders, several studies have addressed lithium-related
neurotoxicity and the related risk factors; these studies all emphasize the relatively narrow therapeutic index of lithium.
The dose-limiting side effect of vincristine is peripheral
neurotoxicity.
