And they concluded that patients who develop a high fever in the first 36 hours after treatment are at increased risk for severe neurotoxicity
From this case report, we highlight the excellent response of methylprednisolone on high-dose cytarabine cerebellar toxicity that suggests an immune-mediated mechanism of neurotoxicity
So far, several mechanisms of the cisplatin-induced neurotoxicity
have been proposed.
In Groups PX, GDX, and PX + GDX, cell apoptosis was observed and the number of apoptotic cells was significantly higher than that of Group A, indicating that PX or GDX could induce a significant increase of apoptosis in the OB, which means that apoptosis is involved in neurotoxicity
induced by PX and GDX.
Associated hazards include: acute toxicity (acute lethality at high concentrations only), blood toxicity, immunotoxicity, cardiovascular toxicity, liver toxicity, kidney toxicity, reproductive toxicity, developmental toxicity, and neurotoxicity
Tolerance can happen with either, but tolerance is not neurotoxicity
as it can be reversed by taking breaks.
Here are 10 agents with neuroprotective effects supported by published data that can be considered as add-on to the standard treatments in an effort to mitigate neurotoxicity
and protect the brain from the destructive processes that accompany acute episodes of psychosis, mania, and depression.
After the exclusion of traumatic causes, nontraumatic neurotoxicity
caused by the accumulative baclofen was highly suspected due to the strong history of taking renally-eliminated baclofen, which may cause neurological symptoms in advanced CKD.
Assessment of Bisphenol A (BPA) neurotoxicity
in vitro with mouse embryonic stem cells," Journal of Environmental Sciences, 2015 DOI: 10.
Due to high antioxidant activity the methanol fraction was used to rescue the oxidative stress induced neurotoxicity
in zebrafish embryos.
Since its approval by the Food and Drug Administration in 1970 as treatment for bipolar disorders, several studies have addressed lithium-related neurotoxicity
and the related risk factors; these studies all emphasize the relatively narrow therapeutic index of lithium.
The dose-limiting side effect of vincristine is peripheral neurotoxicity