(redirected from neutrophile)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.


A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
It might be that a graded PTX3 release from the granules of neutrophile granulocytes, independent of total leukocyte count, plays a role.
Cellular defence includes proliferation and activation of lymphocytes as well as induction of phagocytosis of macrophages and neutrophile granulocytes.
The bioassay for inhibition of 5-LOX-mediated LT[B.sub.4] formation was carried out in a 96-well-plate format with stimulated human neutrophile granulocytes as described by Adams et al.
When neutrophile PMN are activated (respiratory burst) they liberate [O.sub.2.sup.-].
Moreover, visfatin/Nampt also inhibits neutrophile apoptosis in clinical and experimental sepsis [71].
We have investigated knipholone, isolated from the roots of Kniphofia foliosa, Hochst (Asphodelaceae), for inhibition of leukotriene biosynthesis in an ex vivo bioassay using activated human neutrophile granulocytes.
Lymphocytes and plasma cells surround the cutaneous lesion and the neutrophiles are attracted to the debris.
When a tissue suffers from I/R, inflammatory cells cause generation of ROS, which increases leukocyte activation (particularly neutrophiles) and leads to tissue damage and apoptosis (Liou et al., 2003; Parlakpinar et al., 2005).
Laboratory results were as follows: WBC: 7.6, Hgb: 9.7, Hct: 29.7, and platelets: 184 with a differential of neutrophiles: 42.7, monocytes: 11.8, lymphocytes: 44.3, and eosinophils: 1.0.
Most species of SRB that have been isolated from acidic mine waste such as Desulfosarcina, Desulfococcus, Desulfovibrio, and Desulfomonile are neutrophiles and are active at neutral pH [14,25].
Many studies describe changes induced by physical exercise on subtypes of blood mononuclear cells (neutrophiles, lymphocytes, and monocytes) [79, 80].
However, when the same ROS are produced by activated neutrophiles, macrophages destroy microbes/viruses and neighboring cells via oxidative bursts [5].

Full browser ?