Neutrophil

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Related to neutrophilic: neutrophilic leukocytosis

neutrophil

[′nü·trə‚fil]
(histology)
A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.

Neutrophil

 

(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

References in periodicals archive ?
Diagnosis of Pyoderma Gangrenosum following Von den Driesh's criteria Major criteria * Primarily sterile ulceration with undermined borders * Differential diagnosis and exclusion of other pathologies Minor Criteria * Histologic findings not specific, but useful in the exclusion of other disease, characterized by a massive neutrophilic infiltrate.
Isolation and characterization of novel psychrophilic, neutrophilic, Fe-oxidizing chemolithoautotrophic alpha- and gamma-Proteobacteria from the deep-sea.
Presence of neutrophilic infiltrate in the epidermis with dilated adnexal ducts was observed in Pityrosporum folliculitis.
Colchicine was preferred to suppress neutrophilic inflammation.
Histological examination of the lesions on the patient's right breast and abdomen revealed a dermal-epidermal neutrophilic infiltrate with abscess, ulcer formation, and superficial vessels with fibrin deposition (Fig.
Sweet first described acute febrile neutrophilic dermatosis in 1964.
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Patients with liver cirrhosis suffer from immunosuppression due to multiple reasons such as decreased phagocytic activity of neutrophilic granulocytes and the mononuclear phagocytic system deteriorated humoral immunity and decreased opsonin activity of ascitic fluid16.
It was in 12 % cases predominantly neutrophilic and 20 % cases predominantly lymphocytic.
By microscopy, the most noteworthy lesions included marked lymphoplasmacytic and neutrophilic meningoencephalitis, optic nerve perineuritis, and hypophysitis.
US-based therapeutic antibodies company XOMA (NasdaqGM:XOMA) stated on Monday that it has received the Orphan Drug Designation from the US Food & Drug Administration (FDA) for gevokizumab for the treatment of pyoderma gangrenosum (PG), a rare neutrophilic dermatosis of painful expanding necrotic skin ulcers.