niacin


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niacin:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.

niacin

[′nī·ə·sən]
(biochemistry)
References in periodicals archive ?
Pellagra is a nutritional disorder caused by the deficiency of niacin and is characterized classically with three 3 Ds, namely dermatitis, diarrhea and dementia.1 These classical manifestations are rarely seen nowadays, especially due to dietary deficiency alone.2 We report a case of pellagra with the classical dermatological manifestations on the hands and feet but no involvement of the facial and neck region.
Before the statin era, the Coronary Drug Project RCT (8341 patients) showed that niacin monotherapy in patients with definite electrocardiographic evidence of previous myocardial infarction (MI) reduced nonfatal MI to 8.9% compared with 12.2% for placebo (P=.002).
At 90 days of age, 32 rabbits of similar body weight (1,860 [+ or -] 100 g) were divided into 2 groups (16 replicates per group and 1 rabbit per replicate): Fed basal diet (control, measured niacin content was 28 mg/kg) or fed basal diet with 200 mg/kg niacin addition (niacin, measured niacin content was 230 mg/kg).
Each bottle of the patient's energy drink contained 40mg of niacin - twice the recommended daily intake.
However, niacin may also have value in the treatment of schizophrenia, senile dementia, and some other conditions.
Niacin can be directly absorbed by the gastrointestinal tract or synthesized from Tryptophan.
Slo-Niacin tablets utilize a unique polygel controlled-release system--not available in other dietary supplement niacin products--that gradually releases nicotinic acid into the body and is designed to reduce the likelihood of flushing, which is commonly associated with immediate-release niacin use.
"We believe that [our] findings are likely to be generalizable to all high-dose niacin formulations," and any potential benefits of the therapy must be weighed against those important hazards, reported Martin J.
New details from two studies reveal more side effects from niacin, a drug that hundreds of thousands of Americans take for cholesterol problems and general heart health.