pellagra

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Related to niacin deficiency: pellagra, Thiamine deficiency

pellagra

(pəlăg`rə), deficiency disease due to a lack of niacin (nicotinic acid), one of the components of the B complex vitamins in the diet. Niacin is plentiful in yeast, organ meats, peanuts, and wheat germ. The disease manifests itself in lesions of the skin and mucous membrane, diarrhea and other gastrointestinal symptoms, neurological derangement, and mental confusion. It is most common in areas where the diet consists mainly of corn, which, unlike other grains, lacks niacin as well as the amino acid tryptophan, which the body uses to synthesize the vitamin. Treatment includes large doses of niacin and the institution of a proper diet to prevent recurrences.

Bibliography

See D. A. Roe, A Plague of Corn: A Social History of Pellagra (1973).

Pellagra

 

avitaminosis caused by a vitamin PP (nicotinic acid) deficiency. It is manifested by disorders of the skin (dermatitis, generally on the face and neck), alimentary canal (ulceration of the lingual and intestinal mucosa and impairment of gastric secretion and motility), and nervous system (polyneuritis). Treatment involves the administration of nicotinic acid, usually combined with other B-complex vitamins, and adherence to a balanced diet, which includes foods rich in the B vitamins (yeast, liver, eggs, beans) and tryptophan (milk), from which vitamin PP is synthesized in the body.

REFERENCE

Efremov, V. Pellagra: Etiologiia, patogenez i klinika. Moscow-Leningrad, 1934.

pellagra

[pə′lag·rə]
(medicine)
A disease caused by nicotinic acid deficiency characterized by skin lesions, inflammation of the soft tissues of the mouth, diarrhea, and central nervous system disorders.

pellagra

Pathol a disease caused by a dietary deficiency of nicotinic acid, characterized by burning or itching often followed by scaling of the skin, inflammation of the mouth, diarrhoea, mental impairment, etc.
References in periodicals archive ?
This is a classic case of a mental disorder induced by niacin deficiency (pellagra).
It is believed that the main classical clinical abnormalities are a consequence of niacin deficiency.
It should be noted that not only niacin deficiency, but also zinc deficiency can lead to skin symptoms [27].
A vitamin C deficiency causes bleeding skin and gums; niacin deficiency results in a red scaly rash; lack of riboflavin causes redness and cracking at the corners of the mouth; deficiencies of zinc, essential fatty acids or protein produce redness, skin lesions and hair loss.