nicotinamide adenine dinucleotide

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Related to nicotinamide adenine dinucleotide: nicotinamide adenine dinucleotide phosphate, adenosine triphosphate

nicotinamide adenine dinucleotide


nicotinamide adenine dinucleotide phosphate:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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Nicotinamide adenine dinucleotide (NAD)

An organic coenzyme and one of the most important components of the enzymatic systems concerned with biological oxidation-reduction reactions. It is also known as NAD, diphosphopyridine nucleotide (DPN) coenzyme I, and codehydrogenase I. NAD is found in the tissues of all living organisms. See Coenzyme

The nicotinamide, or pyridine, portion of NAD can be reduced chemically or enzymatically with the formation of reduced or hydrogenated NAD (NADH). NAD functions as the immediate oxidizing agent for the oxidation, or dehydrogenation, of various organic compounds in the presence of appropriate dehydrogenases, which are specific apoenzymes, or protein portions of the enzyme. In the dehydrogenase reactions one hydrogen atom is transferred from the substrate to NAD, while another is liberated as hydrogen ion.

NAD and its reduced form, NADH, serve to couple oxidative and reductive processes and are constantly regenerated during metabolism. Hence, they serve as catalysts and NAD is referred to as a coenzyme. In some enzymatic reactions a different coenzyme, triphosphopyridine nucleotide is required. Dehydrogenases are generally quite specific with respect to the coenzyme which they can utilize. See Enzyme, Nicotinamide adenine dinucleotide phosphate (NADP)

Nicotinamide Adenine Dinucleotide


(NAD; also called diphosphopyridine nucleotide, or DPN; obsolete terms, cozymase, coenzyme I, and codehydrogenase I), a coenzyme present in all living cells. NAD is a member of a group of enzymes—the dehydrogenases—that catalyze oxidation-reduction reactions. NAD was discovered in 1904 in yeast juice by the British biochemists A. Harden and W. Young, and its structure was established in 1936 by O. Warburg and H. Euler. The NAD molecule consists of adenine (1), nicotinic acid amide (2), two radicals of the carbohydrate ribose (3), and two phosphate radicals (4). Another very important coenzyme—nicotinamide adenine dinucleotide phosphate, or NADP—contains in its molecule still another phosphate radical bound to the 21-carbon of the ribose radical. The two coenzymes have the following structure:

In many oxidation-reduction reactions, NAD or NADP binds a proton and two electrons transferred from an oxidizable substrate to an oxidized coenzyme. In the reverse reaction, hydrogen is transferred from the reduced coenzyme to the substrate. Meanwhile, hydrogen is uncoupled and attached to the 4-carbon of the nicotinic acid amide:

Both NAD and NADP participate in carbohydrate, protein, and fat metabolism.


nicotinamide adenine dinucleotide

[‚nik·ə′tin·ə‚mīd ′ad·ən‚ēn dī′nü·klē·ə‚tīd]
References in periodicals archive ?
sup][6] CD38 is the major adenosine diphosphate (ADP)-ribosyl cyclase in mammals and uses nicotinamide adenine dinucleotide (NAD [sup]+) to produce ADPR and a small portion of cADPR.
Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease.
KEY WORDS: Alcohol and other drug (AOD) consumption; ethanol metabolism; liver; mitochondria; genetic theory of AOD use (AODU); Wistar rats; UChA rats; UChB rats; aldehyde dehydrogenase (ALDH); ALDH2; acetaldehyde; nicotinamide adenine dinucleotide (NAD); protective factors; chemical aversion
The various test methods employed by self-monitoring glucose devices used by diabetics at home, point-of-care analyzers, and laboratory glucose assays, she pointed out, all use one of the following test methods: glucose hexokinase, glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ), glucose dehydrogenase nicotinamide adenine dinucleotide (GDH-NAD), and glucose oxidase reaction.
Reducing equivalents of NADH (reduced nicotinamide adenine dinucleotide), NADPH (reduced nicotinamide adenine dinucleotide phosphate), and FAD[H.
Utilization of oxygen and reduces nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.
Nicotinamde and ATP together serve as precursors for the coenzyme nicotinamide adenine dinucleotide (NAD).
Nicotinamide adenine dinucleotide (NADH), dietary supplements, corticosteroids, and antidepressants other than selective serotonin reuptake inhibitors (SSRIs) are under study; efficacy should be monitored, Immunotherapy and prolonged rest are unlikely to be beneficial and should not be used.
Superoxide anion production secondary to the assembly of the PMN nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) oxidase is a standard measure of PMN activation.
We have recently used just such a method, coupled with a Laue x-ray diffraction experiment, to define the structure of the Miehaelis complex of the enzyme isocitrate dehydrogenase (IDH), its substrate isocitrate, cofactor nicotinamide adenine dinucleotide phosphate (NADP+) and magnesium [2].
The reason why nicotinamide riboside is such a potent promoter of healthspan and lifespan is because once it enters the body, it converts to one of the most essential factors in energy production in cells, nicotinamide adenine dinucleotide (NAD+).
Fasting blood glucose levels were measured on Glucometer (Optium Medisense) that works by electrical current produced by chemical reaction between glucose and glucose dehydrogenase, nicotinamide adenine dinucleotide (NAD), and phenanthelin quinine present on the glucose strip.

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