nicotinic acid


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Related to nicotinic acid: nicotinic acid deficiency

nicotinic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.

Nicotinic Acid

 

(also niacin, vitamin PP [pellagra-preventive factor], or 3-pyridinecarboxylic acid), a water-soluble vitamin of the B complex. It forms colorless crystals with a melting point of 234°-237°C. Its structural formula is

Nicotinic acid is widespread in living organisms. Yeast, wheat bran, meat, and especially liver and kidneys contain the richest concentration of the vitamin. The nicotinic acid amide—nicotinamide—a constituent of the important coenzymes NAD and NADP, also possesses vitamin activity.

Symbiotic bacteria, chiefly from the intestinal flora, and many animals synthesize nicotinic acid from tryptophan. In rats, mice, and man, tryptophan is converted to nicotinic acid partially by the activity of the intestinal microflora but mainly in the liver. The role of nicotinic acid in the body is to maintain the normal condition of the epidermis, of the epithelium of the alimentary canal, and nervous system function. The vitamin does so by participating as a constituent of coenzymes in many enzymatic processes.

The daily nicotinic acid requirement of man is about 20 mg. A deficiency of nicotinic acid results in pellagra. As a vitamin preparation, nicotinic acid is used as a specific agent in the treatment of several pathological conditions, including pellagra, gastrointestinal diseases, liver disorders, vascular spasm, and atherosclerosis.

nicotinic acid

[¦nik·ə¦tin·ik ′as·əd]
(biochemistry)
C6H5NO2 A component of the vitamin B complex; a white, water-soluble powder stable to heat, acid, and alkali; used for the treatment of pellagra. Also known as niacin.
References in periodicals archive ?
To observe binding of nicotine and its pharmaceutical derivatives, environmentally sensitive hydrogels were placed in aqueous solutions of nicotine, nicotinic acid, nicotinamide and nikethamide, and allowed to equilibrate for 1 day.
Slo-Niacin tablets utilize a unique polygel controlled-release system--not available in other dietary supplement niacin products--that gradually releases nicotinic acid into the body and is designed to reduce the likelihood of flushing, which is commonly associated with immediate-release niacin use.
Stephen, "Influence of nicotinic acid on serum cholesterol in man," Archives of Biochemistry and Biophysics, vol.
Foliar application of vitamin C, nicotinic acid and Curcuma longa extract, were sprayed twice with freshly prepared solutions (water extract) at 45 and 60 days from planting with low and high concentration of all foliar application ingredients, as well as untreated plants (control; distilled water).
Conclusion: Nicotinic acid is the most effective agent available in increasing HDL cholesterol and lowering serum TC, triglycerides (TG), LDL cholesterol and TL in hypercholesterolemic Diabetic and hypercholesterolemic non-diabetic Albino rats.
And at higher doses, nicotinic acid can also lower triglyceride levels.
Large therapeutic amounts of niacin should be provided in the form of nicotinamide, which does not produce the side effects encountered when nicotinic acid is administered.
Fulminant hepatic failure after ingestion of sustained-release nicotinic acid. Ann Intern Med.
Series 2 examined FA oxidation and its dependence on FA levels, using nicotinic acid as an antilipolytic agent.
Hou, "Nicotinic acid hydroxamate downregulated the melanin synthesis and tyrosinase activity through activating theMEK/ERK and AKT/GSK3[beta] signaling pathways," Journal of Agricultural and Food Chemistry, vol.
Nicotinic acid is synthesized from the amino acid tryptophan, so niacin deficiency can directly influence the synthesis of respiratory enzymes and indirectly influence the synthesis of serotonin.
Nicotinamide is a water-soluble vitamin of the B complex, which together with nicotinic acid belongs to vitamin B3 or vitamin PP.