nicotinic acid


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Related to nicotinic acid: nicotinic acid deficiency

nicotinic acid:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.

Nicotinic Acid

 

(also niacin, vitamin PP [pellagra-preventive factor], or 3-pyridinecarboxylic acid), a water-soluble vitamin of the B complex. It forms colorless crystals with a melting point of 234°-237°C. Its structural formula is

Nicotinic acid is widespread in living organisms. Yeast, wheat bran, meat, and especially liver and kidneys contain the richest concentration of the vitamin. The nicotinic acid amide—nicotinamide—a constituent of the important coenzymes NAD and NADP, also possesses vitamin activity.

Symbiotic bacteria, chiefly from the intestinal flora, and many animals synthesize nicotinic acid from tryptophan. In rats, mice, and man, tryptophan is converted to nicotinic acid partially by the activity of the intestinal microflora but mainly in the liver. The role of nicotinic acid in the body is to maintain the normal condition of the epidermis, of the epithelium of the alimentary canal, and nervous system function. The vitamin does so by participating as a constituent of coenzymes in many enzymatic processes.

The daily nicotinic acid requirement of man is about 20 mg. A deficiency of nicotinic acid results in pellagra. As a vitamin preparation, nicotinic acid is used as a specific agent in the treatment of several pathological conditions, including pellagra, gastrointestinal diseases, liver disorders, vascular spasm, and atherosclerosis.

nicotinic acid

[¦nik·ə¦tin·ik ′as·əd]
(biochemistry)
C6H5NO2 A component of the vitamin B complex; a white, water-soluble powder stable to heat, acid, and alkali; used for the treatment of pellagra. Also known as niacin.
References in periodicals archive ?
As with other nicotinic acid medicinal products, caution should be used when Tredaptive is used in patients with unstable angina or in the acute phase of an MI, particularly when such patients are also receiving vasoactive medicinal products such as nitrates, calcium channel blockers, or adrenergic blocking agents.
To observe binding of nicotine and its pharmaceutical derivatives, environmentally sensitive hydrogels were placed in aqueous solutions of nicotine, nicotinic acid, nicotinamide and nikethamide, and allowed to equilibrate for 1 day.
If the label doesn't explicitly list nicotinic acid as the main niacin ingredient, put it back on the shelf and reach for another.
KEY WORDS: Nicotinic acid, Lipid profile, Diabetic and non diabetic Hyper-cholesterolemic rats.
In fact, nicotinic acid, but not nicotinamide, is known to decrease plasma fatty acids, triglyceride, and LDL by reducing lipase effects in adipose tissue and presumably increase HDL concentration by increasing apoA-1 which is the main lipoprotein of HDL [28, 29].
200g) Statins, fibrates, nicotinic acid, cholesterol absorption inhibitors, anion-exchange resins, omega-3 fatty acids: which drugs for which patients?
2Composition of vitamin and trace element premix was as follows per kilogram of premix: vitamin A, 9,000,000 IU; vitamin D3, 2,000,000 IU; vitamin B1, 1,800 mg; vitamin B2, 6,600 mg; vitamin B3, 10,000 mg; vitamin B6, 3,000 mg; vitamin B12,15 mg; vitamin E, 18,000 mg; vitamin K3, 2,000 mg; vitamin B9, 1,000 mg; vitamin B5, 30,000 mg; vitamin H2, 100 mg; folic acid, 21 mg; nicotinic acid, 65 mg; biotin, 14 mg; choline chloride, 500,000 mg; Mn, 100,000 mg; Zn, 85,000 mg; Fe, 50,000 mg; Cu, 10,000 mg; I, 1,000 mg; Se, 200 mg.
Executives point out that one of the company's flagship products, a 12-hour nicotinic acid formulation, highlights the effectiveness of CDT technology by drastically reducing the flushing side effect commonly associated with niacin.
Although nicotinic acid is converted to nicotinamide in the body, they have different modes of action and side effects when used in pharmacological doses.