nitric oxide


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nitric oxide

or

nitrogen monoxide,

a colorless gas formed by the combustion of nitrogen and oxygen as given by the reaction: energy + N2 + O2 → 2NO; m.p. −163.6°C;; b.p. −151.8°C;. Nitric oxide readily combines with oxygen or air to form nitrogen dioxide (NO2), which can again be separated by ultraviolet light to produce nitric oxide and highly reactive oxygen atoms. These oxygen atoms combine with hydrocarbons producing noxious compounds that irritate the membranes of living organisms and destroy vegetation. Large amounts of nitric oxide are created by internal-combustion engines and manufacturing processes. Its quantity is greatly reduced by passing the oxide gas through a catalyst, thereby converting it back to its constituent nitrogen and oxygen gases.

In the environment, nitric oxide is a precursor of smogsmog
[smoke+fog], dense, visible air pollution. Smog is commonly of two types. The gray smog of older industrial cities like London and New York derives from the massive combustion of coal and fuel oil in or near the city, releasing tons of ashes, soot, and sulfur
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 and acid rainacid rain
or acid deposition,
form of precipitation (rain, snow, sleet, or hail) containing high levels of sulfuric or nitric acids (pH below 5.5–5.6).
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. Nitric oxide in minute amounts serves as a source of energy in certain bacteria. In the body, it serves as a chemical messenger with a wide range of functions. It acts as a neurotransmitterneurotransmitter,
chemical that transmits information across the junction (synapse) that separates one nerve cell (neuron) from another nerve cell or a muscle. Neurotransmitters are stored in the nerve cell's bulbous end (axon).
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 and is necessary for penile erection. It affects blood pressure and is produced by macrophages in the immune system to help defend against infection and cancer. Despite its usefulness, nitric oxide can have a toxic effect on body cells and has been implicated in Huntington's diseaseHuntington's disease,
hereditary, acute disturbance of the central nervous system usually beginning in middle age and characterized by involuntary muscular movements and progressive intellectual deterioration; formerly called Huntington's chorea.
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 and Alzheimer's diseaseAlzheimer's disease
, degenerative disease of nerve cells in the cerebral cortex that leads to atrophy of the brain and senile dementia and, ultimately, death. The disease is characterized by abnormal accumulation of plaques and by neurofibrillary tangles (malformed nerve
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.

Nitric oxide

An important messenger molecule in mammals and other animals. It can be toxic or beneficial, depending on the amount and where in the body it is released. Initial research into the chemistry of nitric oxide (NO) was motivated by its production in car engines, which results in photochemical smog and acid rain. In the late 1980s, researchers in immunology, cardiovascular pharmacology, neurobiology, and toxicology discovered that nitric oxide is a crucial physiological messenger molecule. Nitric oxide is now thought to play a role in blood pressure regulation, control of blood clotting, immune defense, digestion, the senses of sight and smell, and possibly learning and memory. Nitric oxide may also participate in disease processes such as diabetes, stroke, hypertension, impotence, septic shock, and long-term depression. See Immunology, Neurobiology

Most cellular messengers are large, unreactive biomolecules that make specific contacts with their targets. In contrast, nitric oxide is a small molecule that contains a free radical—that is, an unpaired electron—making it very reactive. Nitric oxide can freely diffuse through aqueous solutions or membranes, reacting rapidly with metal centers in cellular proteins and with reactive groups in other cellular molecules.

Nitric oxide is produced in the body by an enzyme called nitric oxide synthase, which converts the amino acid l -arginine to nitric oxide and l -citrulline. There are three types of nitric oxide synthase: brain, endothelial, and inducible. Both brain and endothelial enzymes are constitutive, that is, they are always present in cells, while the production of inducible nitric oxide synthase can be turned on or off when a system needs nitric oxide. After nitric oxide is produced in specific areas of the body by nitric oxide synthase, it diffuses to nearby cells. Nitric oxide then reacts preferentially in the interior of these cells with the metal centers of proteins. Nitric oxide binds specifically to the iron (Fe) atom of the heme group in proteins; it can also interact with other metal sites in proteins as well as with the thiol group (SH) of the amino acid cysteine. The interaction of nitric oxide with these proteins causes a cascade of intracellular events that leads to specific physiological changes within cells. For example, nitric oxide causes the smooth muscle cells surrounding blood vessels to relax, decreasing blood pressure. Nitric oxide plays an important role in the central and peripheral nervous systems; the overproduction of nitric oxide in brain tissues has been implicated in stroke and other neurological problems.

Nitric oxide also functions as an important agent in the immune system by killing invading bacterial cells. Nitric oxide released by macrophages can inhibit important cellular processes in the bacteria, including deoxyribonucleic acid (DNA) synthesis and respiration, by binding to and destroying iron-sulfur centers in key enzymes in these pathways.

Although nitric oxide production in the immune system serves a crucial biological function, there can be adverse effects when too much nitric oxide is produced. During a massive bacterial infection, excess nitric oxide can go into the vascular system, causing a dramatic decrease in blood pressure, which may lead to possibly fatal septic shock. Thus, scientists are working on drugs that can selectively inhibit the inducible form of nitric oxide synthase in order to avoid the harmful effects produced by excess nitric oxide without interfering with useful nitric oxide pathways.

nitric oxide

[′nī·trik ′äk‚sīd]
(inorganic chemistry)
NO A colorless gas that, at room temperature, reacts with oxygen to form nitrogen dioxide (NO2, a reddish-brown gas). It may be used to form other compounds. It is a crucial physiological messenger molecule thought to play a role in blood pressure regulation, control of blood clotting, immune defense, digestion, the senses of sight and smell, and possibly learning and memory.
References in periodicals archive ?
That's because nitric oxide production starts in your mouth.
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Although the interest in nitric oxide may have somewhat diminished over the last decade, methods to measure nitric oxide (metabolites) are still used extensively.
Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: Results of randomised phase II trial.
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothielial cells.
Even after diagnosis, the measurement of exhaled nitric oxide has clinical utility because elevated levels can guide treatment decisions, he explained.
Nitric oxide, the biological mediator of the decade: Fact or fiction?
HDL is the most potent stimulator of nitric oxide production that we have found in the past decade.
Polymeric nitric oxide release represents a unique strategy, particularly since nitric oxide has a short half-life in blood -- just a few seconds -- and thus would only have an effect on areas near the implant site where it is needed most.
After gaining approval, Sumitomo Seika Chemicals will start importing nitric oxide gas from INO as early as next October and Air Water will sell it to hospitals nationwide, they said.
But in a study of 21 consecutive UCLA lung transplant patients given 20 ppm nitric immediately postoperatively, 16 experienced no reperfusion injury and were weaned from nitric oxide and mechanical ventilation within 24 hours of transplantation, according to Abbas Ardehali, MD, who reported his group's findings at the annual meeting of the Society of Thoracic Surgeons in San Antonio, Texas in early February.
The findings that nitric oxide, a gas, has such a key role in the human body ``represented an entirely new principle for signalling in biological systems,'' wrote the Nobel committee.