Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to nitroglycerin: nitroglycerin tablets


(nī'trōglĭs`ərĭn), C3H5N3O9, colorless, oily, highly explosive liquid. It is the nitric acid triester of glycerolglycerol,
or 1,2,3-propanetriol
, CH2OHCHOHCH2OH, colorless, odorless, sweet-tasting, syrupy liquid. Glycerol is a trihydric alcohol. It melts at 17.
..... Click the link for more information.
 and is more correctly called glycerol trinitrate. It is insoluble in water but soluble in ether, acetone, benzene, and chloroform. An unstable compound, nitroglycerin decomposes with explosive violence when heated or jarred. It is mixed with an absorbent material to form dynamitedynamite,
explosive made from nitroglycerin and an inert, porous filler such as wood pulp, sawdust, kieselguhr, or some other absorbent material. The proportions vary in different kinds of dynamite; often ammonium nitrate or sodium nitrate is added.
..... Click the link for more information.
 (which is not so sensitive to slight shocks) and is also used as a component of smokeless powder. Nitroglycerin was discovered (c.1847) by the Italian chemist Ascanio Sobrero and was first produced commercially by Alfred NobelNobel, Alfred Bernhard
, 1833–96, Swedish chemist and inventor. Educated in St. Petersburg, Russia, he traveled as a youth and returned to St. Petersburg in 1852 to assist his father in the development of torpedoes and mines.
..... Click the link for more information.
. It is used medicinally to provide temporary relief from the symptoms of angina pectorisangina pectoris
, condition characterized by chest pain that occurs when the muscles of the heart receive an insufficient supply of oxygen. This results when the arteries that supply the heart muscle with oxygenated blood are narrowed by arteriosclerosis.
..... Click the link for more information.
; the body converts it to nitric oxide, which causes narrowed blood vessels to relax.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(glyceryl trinitrate), ONO2CH2—CHO-NO2—CH2ONO2, the triester of glycerol with nitric acid; a powerful explosive.

Nitroglycerin is an oily, colorless liquid that crystallizes in two modifications: a labile form (melting point, 2.8°C) and a stable form (melting point, 13.5°C). Density, 1.591 g/cm3 (25°C). Nitroglycerin is virtually insoluble in water but readily soluble in acetone, ether, and benzene. It explodes upon even a slight impact. Heat of explosion, 6.3 megajoules per kg, or 1,500 kcal/kg; detonation rate, 7.7 km/sec; volume of gaseous explosion products, 713 liters per kg; flash point, ∼200°C.

Nitroglycerin is produced by nitration of glycerol with a nitrating mixture. It is used in significant quantities as a secondary explosive in the production of dynamites and various propellants.

Nitroglycerin produces dilation of the cardiac blood vessels; it is used in medical practice in the form of an ethanol solution (in drops) and in tablets to relieve attacks of angina pectoris.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


(organic chemistry)
CH2NO3CHNO3CH2NO3 Highly unstable, explosive, flammable pale-yellow liquid; soluble in alcohol; freezes at 13°C and explodes at 260°C; used as an explosive, to make dynamite, and in medicine. Also spelled nitroglycerine.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


, nitroglycerin
a pale yellow viscous explosive liquid substance made from glycerol and nitric and sulphuric acids and used in explosives and in medicine as a vasodilator. Formula: CH2NO3CHNO3CH2NO3
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Of the 6 426 patients, 3 174 (31.8% menopausal) were treated with local nitroglycerin application and 3 252 (68.2% menopausal) comprised the control group.
In our study, no patients in dexmedetomidine group required nitroglycerin for controlled hypotension while 40 patients in control gp required nitroglycerin for controlled hypotension.
Our study results showed that the addition of 5 mg transcutaneous nitroglycerin patch as adjuvant to Bier's block reduced the lidocaine dose to 1.5 mg/kg of 0.25% lidocaine; reduced the onset times of sensory and motor block, VAS scores, and analgesic consumption; prolonged the sensory and motor block recovery times and the duration of postoperative analgesic effect of Bier's block; delayed the first time to analgesic requirement; and improved the quality of Bier's block with no adverse effects.
Sublingual or intravenous nitroglycerin or isosorbide dinitrate are effective in the improvement of anginal episodes (Yasue 2008).
Meine, MD, and colleagues found that use of morphine either alone or in combination with nitroglycerin for patients presenting with non--ST-elevation acute coronary syndrome (NSTE-ACS) was associated with higher mortality.
The first related to cases where a nitroglycerin ban was introduced in Sweden in 1868, the Nobel Company influenced the decision to impose prohibition.
Our case report is unique in that it is the first documented case of nitroglycerin sublingual therapy to successfully treat suspected ophthalmic artery vasospasm.
If 3 hours after starting oral antihypertensive combination either the Mean Arterial Pressure (MAP)/Diastolic Blood Pressure (DBP) is found to be more than 125 mmHg/105 mmHg, then injection nitroglycerin infusion (5) is administered at 5 microgram/kg/min.
Each individual packet of GONITROTM contains 400 mcg of nitroglycerin. The clinical data indicate that the sublingual absorption of nitroglycerin is higher following the administration of GONITROTM compared to Nitrolingual Pumpspray (nitroglycerin lingual spray) which was launched in 1997 and is currently marketed by Espero in the U.S.
In concept, nuclear fracturing is much like "shooting" a well with nitroglycerin; each method relies on an explosion to produce shock waves which fracture the rock.
Increasing evidence suggests that the aldehyde dehydrogenase 2 (ALDH2) (G-504-A) gene polymorphism is associated with nitroglycerin (NTG) inhibition.
The reported study evaluated the disappearance of nitroglycerin as applied in commercial smokeless powder (SP), in compost prepared from vegetative matter.