The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors
. Front Mol Neurosci 2017; 10: 181.
To verify the analgesic effect, a sensibility test was conducted by lightly pressing a needle to the lip of each fish, where nociceptor
fibres are usually found (Sneddon, 2003).
Reeh, "Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
," Physiological Reviews, vol.
Walters, "TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors
after spinal cord injury," Pain, vol.
Neurons in TGs are also known to have nociceptors
and neurochemical properties similar to that of DRG neurons .
in the nasal mucosa consist of myelinated and unmyelinated fibers.
have demonstrated that sensitization of nociceptors
and depression of cold thermoreceptor activity can occur in UV-induced keratitis in guinea pigs .
The decrease in parasympathetic activity may be due to sustained stimulation of the nociceptors
which might be the cause for the shifting of sympathovagal balance toward sympathetic side in the patients suffering from the AS.
Under physiological conditions, potentially harmful stimuli are integrated by the nociceptors
of primary afferent fibers and relayed for final processing in the supraspinal centers.
Intradiscal electrothermal treatment has been used by specialists for more than ten years in discogenic pain treatment.3 Collagen structure of the disc is changed and nociceptors
are coagulated by penetrating into nucleus pulposus through annulus fibrosis posterior using a percutaneous needle or a cannula in intradiscal treatment techniques similar to IDET.3 Clinical success of the procedure is generally about 60%.3 Complications may develop after the procedure.
Acute pain begins with activation of peripheral nociceptors
at the site of injury.
Sensitization in migraine may have a peripheral component with local release of inflammatory markers, which would certainly activate trigeminal nociceptors
, although a peripheral component is not necessary to explain the symptoms.