nodular goiter


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nodular goiter

[′näj·ə·lər ′gȯid·ər]
(medicine)
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The clinical syndrome of thyrotoxicosis can be caused by many diseases, the two most common causes are Graves' Disease (GD) and Toxic Nodular Goiter (TMNG).
Ninety-nine patients (43.4%) with FNMTC had concurrent nodular goiters and 29 patients (13.9%) had concurrent Hashimoto's thyroiditis.
Pathology Regular high- Regular no- enhancement enhancement ring n (%) ring n (%) Benign Adenoma 20 (28.6%) 5 (41.7%) Nodular goiters 40 (57.1%) 2 (16.7%) Hashimoto thyroiditis 8 (11.4%) 2 (16.7%) Granulomatous thyroiditis 1 (1.4%) 0 Malignant Papillary thyroid carcinoma 0 3 (25%) Medullary carcinomas 1 (1.4%) 0 Total 70 12 Pathology Irregular Irregular high-enhancement no-enhancement ring n (%) ring n (%) Benign Adenoma 0 0 Nodular goiters 0 0 Hashimoto thyroiditis 0 0 Granulomatous thyroiditis 0 0 Malignant Papillary thyroid carcinoma 13 (100%) 24 (96%) Medullary carcinomas 0 1 (4%) Total 13 25 Table 3: The conventional US and CEUS findings of thyroid benign and malignant nodules.
Only patients with nodular goiter were included in the study and not those with a diffuse goiter.
In a study carried out by Fassbender et al.(37) on 102 patients that 16 had nodular thyroid gland, 15 had diffuse goiter and 34 had nodular goiter. It was observed that functional parameters changed related to thyroid morphology following coronary angiography even though the patients had no hyperthyroidism.
Management of simple nodular goiter current status and future perspectives.
of cases -Clinical Cytological- (Percentage) FNA and FNC (Percentage) Multinodular goiter 42(84%) 25(50%) Solitary nodule 5(10%) 0(0%) Colloid goiter 0(0%) 10(20%) Toxic nodular goiter 1(2%) 1(2%) Hashimoto's thyroiditis 0(0%) 6(12%) Papillary Carcinoma 2(4%) 1(2%) Follicular neoplasm(FN) 0(0%) 2(4%) Adenomatous nodule(AN) 0(0%) 2(4%) Adenomatous nodular 0(0%) 1(2%) hyperplasia(ANH) Lymphocytic thyroiditis(LT) 0(0%) 1(2%) Anaplastic carcinoma 0(0%) 1(2%) Total 50(100%) 50(100%) Table 4: Comparison between FNCC and FNAC diagnosis.
Data for patients with Graves' disease and toxic nodular goiter are presented in Tables No.
It is in accordance to a recent study in Pakistan conducted by Tariq N etal 2007 which showed 56.9% of nodular goiter and 23.08% of follicular neoplasm.
DIFFERENTIAL DIAGNOSIS: Parathyroid hyperplasia, parathyroid adenocarcinoma, thyroid carcinoma, solitary toxic nodular goiter, ectopic thyroid, and parathyroid adenoma.

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