Because the liquid-based specimen can be stored without compromising DNA integrity, this method can be used in smaller cytopathology laboratories in which molecular testing may not be performed up front in all newly diagnosed non-small cell carcinoma
However, adenocarcinoma can also be quite challenging to diagnose because there is substantial overlap of cytologic features between adenocarcinoma and other poorly differentiated non-small cell carcinomas
. (11) This difficulty is further highlighted by the participant interpretations of non-small cell carcinoma
Keratin and Vimentin Expression in Carcinomas and Mesenchymal Tumors Carcinomas That Frequently Express Both Renal cell carcinoma Anaplastic thyroid carcinoma Endometrial carcinoma Thyroid carcinoma Sarcomatoid carcinoma Mesothelioma Myoepithelial carcinoma Metaplastic breast carcinoma Carcinomas That Rarely Express Both Breast carcinoma Ovarian carcinoma Gastrointestinal carcinoma Lung small cell carcinoma Lung non-small cell carcinoma
Prostate carcinoma Mesenchymal Tumors That Frequently Express Both Synovial sarcoma Desmoplastic small round blue cell tumor Epithelioid sarcoma Epithelioid angiosarcoma Malignant rhabdoid tumor Leiomyosarcoma Chordoma Adamantinoma Table 4.
The IASLC reproducibility study of poorly differentiated, non-small cell carcinoma
demonstrated great agreement among pulmonary pathologists in recognizing features of squamous cell carcinoma, such as keratinization, pearl formation, and intercellular bridges.
Previous Studies Outlining Accuracy of Cytologic Subclassification of Non-Small Cell Carcinoma
of the Lung Type of Specimen Cytology Accuracy No.
(2) Confirmation of a cancer diagnosis or a diagnosis of non-small cell carcinoma
of the lung is no longer adequate for clinical management because targeted therapies for a subset of advanced lung ACAs have become available in recent years following the development of small molecule tyrosine kinase inhibitors.
Original Diagnosis 1 Large cell carcinoma 2 Undifferentiated large cell carcinoma 3 Undifferentiated large cell carcinoma 4 Poorly differentiated carcinoma 5 Undifferentiated large cell carcinoma 6 Poorly differentiated non-small cell carcinoma
7 Poorly differentiated carcinoma 8 Undifferentiated large cell carcinoma 9 Poorly differentiated carcinoma 10 Undifferentiated large cell carcinoma 11 Non-small cell carcinoma
12 Undifferentiated large cell carcinoma 13 Large cell undifferentiated carcinoma 14 Poorly differentiated carcinoma with squamous features 15 Poorly differentiated non-small cell carcinoma
16 Poorly differentiated non-small cell carcinoma
17 Undifferentiated large cell carcinoma Case, No.
The potential role for such a biomarker, PD-L1, was investigated in this setting of treatment for non-small cell carcinoma
. In 2 studies, (8,9) nivolumab was assessed in comparison to docetaxel in the treatment of squamous cell carcinoma of the lung and subsequently in the treatment of non-small cell, nonsquamous lung cancer.
Reference diagnoses included non-small cell carcinoma
, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, carcinoid tumor, and metastatic carcinoma not otherwise specified.
(1,2) Platinum-based chemotherapy constitutes the standard first-line treatment for stage IV non-small cell carcinoma
of the lung, but 5-year survival remains approximately 2% for these patients.