noncompetitive inhibition


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Related to noncompetitive inhibition: Uncompetitive inhibition

noncompetitive inhibition

[¦nän·kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor can combine with either the free enzyme or the enzyme-substrate complex so that the inhibitor does not compete with the substrate for the enzyme.
References in periodicals archive ?
(a) AChE and metformin at concentration of 2.35 [micro]mol/mL ([IC.sub.50]), mixed-type inhibition; (b) AChE and prodrug 1 at concentration of 0.89 [micro]mol/mL ([IC.sub.50]), noncompetitive inhibition; (c) BuChE and prodrug 1 at concentration of 0.028 [micro]mol/mL ([IC.sub.50]), mixed-type inhibition.
HTOR inhibited CYP2J2-catalyzed astemizole Odemethylation activity with K1 value of 11.1 [micro]M in a noncompetitive inhibition mode.