noncompetitive inhibition


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Related to noncompetitive inhibition: Uncompetitive inhibition

noncompetitive inhibition

[¦nän·kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor can combine with either the free enzyme or the enzyme-substrate complex so that the inhibitor does not compete with the substrate for the enzyme.
References in periodicals archive ?
Noncompetitive inhibition is a result of binding of the inhibitors containing electrophilic groups (imidazole or hydrazine group) to the haem protein of CYP (Lewis et al.
Among the tanshinones studied, only cryptotanshinone competitively inhibited CYP2E1 activity in pooled human liver microsomes, while tanshinone I showed noncompetitive inhibition (Table 2).