I think that to do a noninferiority trial
, you need very, very large numbers because you really need to be able to demonstrate that you've properly tested the hypothesis and found no difference between those groups.
The PEARL II study was a noninferiority trial
comparing the same two doses of daily oral ulipristal against once-monthly leuprolide injections for the preoperative treatment of fibroids in 307 women.
Randomized controlled noninferiority trial
to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains.
In a randomized, double-blind, noninferiority trial
among 1,352 patients who had complicated COPD and an exacerbation, about a fifth of patients had a clinical failure of their antibiotic therapy, no matter which regimen they received, according to results reported at the conference.
This was followed in 2005 by an open-label noninferiority trial
that compared MMF in doses up to 3,000 mg/day with monthly intravenous cyclophosphamide (0.
Analysis was by intent-to-treat, and this was a noninferiority trial
(ie, the researchers were trying to prove that ASA-ERDP was at least as good as clopidogrel, not that it was better).
The investigators performed a randomized, double-blind, noninferiority trial
to directly compare 1 year of prophylaxis with TMP-SMX (one 480-mg tablet once daily) against a capsule containing 500 mg cranberry extract (one capsule twice daily) for preventing recurrent UTI in 221 premenopausal women who had at least three UTIs during the previous year.
Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfornylurea: A multinational, randomized, open-label, two-period, crossover noninferiority trial
The RECORD trial is a drug company-sponsored, open label, randomized, controlled, noninferiority trial
evaluating cardiovascular outcomes in 4,447 patients with type 2 diabetes assigned to receive either rosiglitazone in addition to their ongoing metformin or sulfonylurea therapy (n = 2, 220) or a combination of metformin and sulfonylurea (n = 2,227).
Design and Setting: This randomized, open-label, outcome adjudicator-blinded, noninferiority trial
was conducted at university-affiliated clinical centers in Canada and New Zealand.
But they agreed that the effect of treatment in the study was not robust and recommended that nebivolol be studied further in a noninferiority trial
of heart failure patients, where it would be compared to one of the two beta-blockers approved for treating heart failure, carvedilol or extended-release metoprolol.
in a noninferiority trial
involving physicians from multiple specialties.