(redirected from noninferiority trial)
Also found in: Dictionary, Thesaurus, Medical, Legal.
Related to noninferiority trial: equivalence trial, superiority trial


procedure, in law, the rules that govern the obtaining of legal redress. This article deals only with civil procedure in Anglo-American law (for criminal procedure, see criminal law). Except for evidence, procedure conventionally embraces all matters concerning legal actions that come to trial; thus, procedure is the means for enforcing the rights guaranteed by the substantive law.

Current Civil Procedure

A legal action, in its simplest form, is a proceeding of a plaintiff against a defendant from whom redress is sought. The plaintiff begins a lawsuit by filing a complaint, a written statement of his or her claim and the relief desired, with a court that has jurisdiction (authority to hear the case). The defendant is served a process (e.g., a summons) that notifies him or her of the suit and usually responds with an answer. Failure to respond ordinarily entitles the plaintiff to a judgment by default.

Today, liberal rules of pretrial discovery allow parties to a civil action to obtain information from other parties and their witnesses through depositions and other devices. Discovery (i.e., disclosure) is now used to ascertain the facts believed by the other side to exist, and to narrow the issues to be tried. At common law, pleadings performed this function, and they were continued beyond the complaint and answer until an issue was agreed upon.

The issue is one of law if the defendant denies that the alleged acts are a violation of substantive law entitling the plaintiff to relief; it is one of fact if the defendant denies committing any of the alleged acts. The judge rules on an issue of law, and if the judge upholds the defendant the suit is dismissed. An issue of fact is resolved by the presentation of evidence to the jury, or, in cases tried without a jury, by the judge. After the jury has delivered a verdict on the factual issue, the judge renders a judgment, which in most (but by no means all) instances upholds the verdict. At this point the case is closed (unless the losing party prosecutes an appeal), and the plaintiff, if having won, proceeds to execution of the judgment.

Evolution of Procedural Law

Current procedural law has had a long historical evolution. The early common law allowed an action to be brought only if it closely conformed to a writ. Rigorous enforcement of the rule “no writ, no right,” and the small number of available writs acted to deny relief even in meritorious cases and stimulated the growth of equity, which, in its early days, gave redress generously.

By the 19th cent., however, the technical intricacy of equity and law procedure and the tendency to make cases hinge on procedural details rather than on substantive rights made reform imperative. The way was led by the New York code of civil procedure of 1848 (largely the work of David Dudley Field), which abolished the distinction between law and equity (thereby effecting great simplification) and established the cause of action as the procedural cornerstone. A similar reform was accomplished in Great Britain by the Judicature Acts of 1875. Today the procedure of most American jurisdictions is based on codes (like that of New York) rather than on common law and equity, although the influence of these separate categories is still frequently discernible.


See J. Michael, The Elements of Legal Controversy (1948); P. Carrington, Civil Procedure (1969).

The Columbia Electronic Encyclopedia™ Copyright © 2022, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a concept used in probability theory. Trials may have one (and only one) of the outcomes A1, A2,. . ., An Each outcome of a trial is considered an “event” that has a certain probability P(Ak). Here Trial always holds.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

What does it mean when you dream about a trial?

Dreaming of being on trial may indicate that the dreamer needs to be more accepting of himself or herself and less judgmental of others.

The Dream Encyclopedia, Second Edition © 2009 Visible Ink Press®. All rights reserved.


One of a series of duplicate experiments.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


Bardell vs. Pickwick
trial for breach of promise results in imprisonment of both parties for not paying damages and costs. [Br. Lit.: Dickens Pickwick Papers]
Trial by Jury
trial of a breach-of-promise suit is dismissed when the judge decides to many the plaintiff. [Br. Opera: Gilbert and Sullivan Trial by Jury]
Trial, The
Joseph K. is tried by a strange court for an unspecified crime. [Ger. Lit.: Kafka The Trial]
Allusions—Cultural, Literary, Biblical, and Historical: A Thematic Dictionary. Copyright 2008 The Gale Group, Inc. All rights reserved.


1. Law
a. the judicial examination of the issues in a civil or criminal cause by a competent tribunal and the determination of these issues in accordance with the law of the land
b. the determination of an accused person's guilt or innocence after hearing evidence for the prosecution and for the accused and the judicial examination of the issues involved
c. (as modifier): trial proceedings
2. a motorcycling competition in which the skills of the riders are tested over rough ground
3. Ceramics a piece of sample material used for testing the heat of a kiln and its effects
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
This was a multicenter (11 sites), randomized, noninferiority trial. Preoperatively, 630 women with stress-predominant incontinence (and a positive cough stress test) who desired surgical management were randomly assigned to preoperative office evaluation alone or to the addition of urodynamic testing.
The outcomes of the Norwegian, double-blind, noninferiority trial, called NOR-SWITCH, indicate similar rates of disease worsening across patients switched to Remsima and those who stayed on Remicade.
The EINSTEIN PE investigators conducted a randomized, unblinded noninferiority trial to determine whether rivaroxaban was at least as effective as the standard therapy--enoxaparin, followed by a dose-adjusted VKA (warfarin [for US patients] or acenocoumarol) for acute symptomatic PE.
In a randomized, double-blind, noninferiority trial of 1,352 patients who had complicated COPD and an exacerbation, about a fifth of patients had a clinical failure of their antibiotic therapy, no matter which regimen they received, according to results reported at the conference.
Data Source: A phase III noninferiority trial involving 891 women with invasive node-positive breast cancer treated at 115 medical centers.
A recent noninferiority trial in 23 patients with infantile hemangiomas compared atenolol 1 mg /kg per day with propranolol 2 mg/kg per day, and followed the patients for 6 months (J.
Investigators compared the two therapies head to head in I-CAN SLEEP (A Comparison of MBSR and CBT for the Treatment of Insomnia in Cancer), a randomized, partially blinded noninferiority trial among 111 adult patients from a tertiary care center in Calgary, Alta., who had nonmetastatic cancer and were at least 1 month out from completion of treatment.
Outpatient treatment measures up The Outpatient Treatment of Pulmonary Embolism (OTPE) study was a multinational, randomized, noninferiority trial comparing outpatient vs inpatient treatment of low-risk patients with acute PE.
The open-label noninferiority trial was conducted at 11 sites in nine African, Asian, and Latin American countries.
The investigators performed the noninferiority trial, known as the REDUCE (Reduction in the Use of Corticosteroids in Exacerbated COPD) study, because no adequately powered, randomized clinical trial has compared directly the outcomes of these two treatment durations.
The study by Gurtcheff et al was a randomized controlled noninferiority trial of 69 women who wanted to use Implanon for postpartum birth control.