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Enlargement of the spleen.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Small RNA-sequencing data of ccRCC tumours (unpaired (n = 502) and tumours with matched nonmalignant tissue (n = 71)) were obtained from cgHUB and processed, and data were analyzed using the miRDeep2 prediction algorithm through the OASIS platform [20, 23].
All diagnostic tests significantly differentiated malignant adnexal tumors from nonmalignant adnexal tumors in the analysis of the whole group, as well as analysis of the postmenopausal and premenopausal subgroups.
The diagnostic performance of these indices for the differentiation of malignant stage I (FIGO) from nonmalignant adnexal tumors is shown in Table 7.
In conclusion, to our knowledge, this is the first report that describes HBV marker expression within CSCs associated with human HCC and nonmalignant stem cells associated with adjacent non-tumor tissue.
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Austin said that researchers with the Princeton PS-OC determined that metastatic cells, in spite of moving more slowly than nonmalignant cells, move farther and in a straighter line.
They compared the safety profiles of different opioids for the treatment of nonmalignant pain in elderly patients because "relatively little attention has been paid" to this issue even though the use of these drugs has increased by 50%-100% in recent years.
He said the patient, a 57-year-old man, had checked on his condition in a number of local hospitals in the last years and was diagnosed with a nonmalignant gland.
The third case, with LCIS, revealed ductal carcinoma in situ (DCIS), which is a nonmalignant diagnosis, as well as residual LCIS, and calcifications upon excision.
Tumor microenvironment--the nonmalignant host cells adjacent to tumors--is becoming recognized as an important contributor in cancer pathogenesis, progression, and treatment response.
Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells.
Previous studies of Libby workers documented increased risk of lung cancer and nonmalignant respiratory disease among highly exposed workers with at least 1 year tenure (Amandus and Wheeler 1987; McDonald et al.