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Enlargement of the spleen.



in medicine, the enlargement of the spleen. Splenomegaly occurs with diseases of the spleen (tumors, cysts, abscesses), with general infections (sepsis, malaria, typhoid fever, typhus), with blood diseases (leukoses, lymphgranulomatos-es), and with liver diseases. The spleen is examined by palpation while the individual is lying on his side; it will not be felt if its size is normal.

Splenomegaly is often the first manifestation of blood disease. In such cases, splenic puncture is performed in order to make an accurate diagnosis. With chronic leukoses, the spleen may occupy most of the abdomen and weigh as much as 8 kg. Splenomegaly is accompanied by disruption of breathing, blood circulation, and the functions of adjacent organs, including the stomach, intestine, and left kidney. Disturbances of splenic blood circulation (thromboses), suppression of hematopoiesis (hypersplenism), and other complications may also occur. The condition is treated by surgically removing the spleen (splenectomy), by irradiating the spleen with gamma rays, and by administering cytostatics and corticosteroids.

References in periodicals archive ?
In conclusion, to our knowledge, this is the first report that describes HBV marker expression within CSCs associated with human HCC and nonmalignant stem cells associated with adjacent non-tumor tissue.
The analysis presented here focuses on occupational respiratory conditions potentially related to asbestos exposure: lung cancer, asbestosis, and other nonmalignant respiratory disease.
Whereas no one is advocating the elimination of opioids as a tool for treating chronic nonmalignant pain, we should demand at least the same rigor that we demand for other treatments.
During 2004, 2005 and 2006, defendant companies experienced a significant drop in claim filings for nonmalignant injuries.
7 % for patients given transplants for nonmalignant liver conditions.
Nonmalignant leiomyomas show peripheral vascularization, but more than one-third of the leiomyosarcomas also showed a high degree of central vascularization.
Since then, the term Ortner's syndrome has come to encompass any nonmalignant, cardiac, intrathoracic process that results in embarrassment of either recurrent laryngeal nerve--usually by stretching, pulling, or compression--and causes a vocal fold paralysis.
Currently we are developing RELISTOR for the potential treatment of OIC in patients with chronic nonmalignant pain.
The research obtained pleural effusion samples from 78 lung cancer patients with MPE, as well as from 45 patients with nonmalignant pleural effusion.
Taken at face value, these data are very impressive and demonstrate that this micro-NMR technology provides faster, better, and likely cheaper point-of-care data for differentiating malignant from nonmalignant lesions, compared with the cytologic and histochemical techniques, which are slower, require more sample, and are likely more expensive.
In addition to chapters on PDT treatment of esophageal, tracheobronchial, and skin cancers, the text contains chapters on nursing care of the PDT head and neck cancer patient, as well as two nonmalignant conditions of the upper aerodigestive tract--laryngeal papillomas and PDT for bacterial and fungal biofilms.
McNulty of the Palliative Care Institute of Southeast Louisiana presented a case series of 20 of 244 patients with chronic, nonmalignant pain from a palliative care clinic and 11 of 1,508 terminally ill patients with severe chronic pain enrolled in hospice care during a 5-year period.