nonpermissive cell

nonpermissive cell

[‚nän·pər¦mis·iv ′sel]
(virology)
A cell that does not support replication of a virus.
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References in periodicals archive ?
Expression profiling of baculovirus genes in permissive and nonpermissive cell lines.
Analysis of host specificity of two closely related baculoviruses in permissive and nonpermissive cell lines.
The isoform NF-1A, which is expressed in several JCV nonpermissive cell types, has been shown to decrease viral late protein expression, while NF 1X increases viral gene expression and is highly expressed in cells permissive to JCV replication.
In nonpermissive cells, TAg has the ability to dysregulate several signaling pathways such as WNT/[beta]-catenin that is responsible for the control of cell proliferation and IGF IR/IRS-1 pathway involved in DNA repair fidelity [5].
As stated on page 132 of Basic Virology, a nonpermissive cell is one that "for some reason, does not have the proper machinery for virus replication" [12].
A statement later in the text, on page 296, in relation to SV40 replication in nonpermissive cells describes the integration of SV40 DNA into the host genome, noting that it is "entirely random" and "does not occur very frequently" [12], but when it does happen, it can cause cell transformation and cancer.
HPV, adenoviruses, and polyomaviruses induce the host cell transformation while infecting nonpermissive cells and integrating into the host genome (see Table 1).
Family Virus Virus-cell interaction Herpesviruses Epstein-Barr Episomal, rarely virus, EBV integrated in transformed cells Kaposi sarcoma Episomal, rarely herpes virus, integrated in transformed KSHV cells John Cunningham Episomal, rarely Virus, JCV integrated in transformed nonpermissive cells Polyoma viruses Virus of B.K.
Adenovirus stocks were stored in 3% sucrose/phosphate-buffered saline (PBS) at 1-2 x [10.sup.12] particles/mL and confirmed as negative for replication-competent adenovirus by passage on nonpermissive cells.
Production and persistence of gRNA and sgRNA were examined in permissive and nonpermissive cells. Analysis of permissive Veto E6 cells showed that the sgRNA encoding S was not present in the input virus before RNA replication (Figure 1A, 1 h).