nonsteroidal anti-inflammatory drug


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nonsteroidal anti-inflammatory drug,

a drug that suppresses inflammation in a manner similar to steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
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, but without the side effects of steroids; commonly referred to by the acronym NSAID (ĕn`sĕd). Also effective in alleviating pain and fever, NSAIDs are commonly used to treat the symptoms of arthritis, gout, bursitis, painful menstruation, and headache. They act by inhibiting the synthesis of prostaglandins, leukotrienes, and other compounds that are involved in the inflammatory process.

Aspirin is technically an NSAID, but the term is often used to refer to nonaspirin products. The first nonaspirin NSAIDs were introduced in 1964. Common NSAID products include diclofenac (Cataflam, Voltaren), indomethacin (Indocin), ketorolac (Acular, Toradol), and piroxicam (Feldene). Ibuprofenibuprofen
, nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxen and ketoprofen, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967.
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, naproxennaproxen
and naproxen sodium,
potent nonsteroidal anti-inflammatory drugs (NSAID) used to alleviate the minor pain of arthritis, menstruation, headaches, and the like, and to reduce fever.
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, and ketoprofenketoprofen
, nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and fever-reducing effects, used to relieve the symptoms of headaches, arthritis, and painful menstruation.
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 are available as over-the-counter drugs in the United States. The cox-2 inhibitors, such as celecoxib (Celebrex), selectively inhibit clooxygenase-2 (cox-2), an enzyme that causes pain and inflammation in arthritic joints, but do not interfere with cox-1, which protects the stomach and intestinal lining from ulceration. Very common drugs, NSAIDs are taken daily by an estimated 3 million Americans.

Although they are often considered easier to tolerate than aspirin, and most do not have as strong an anticlotting effect as aspirin, NSAIDS can have serious side effects, particularly gastrointestinal ulcers and upper gastrointestinal tract bleeding and perforation in those who take the drugs on a regular basis. NSAID-related gastropathy results in more than 2,000 deaths in the United States each year.

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References in periodicals archive ?
Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient.
"Low-intensity pulsed ultrasound accelerates and a nonsteroidal anti-inflammatory drug delays knee ligament healing," Amer Journ of Sports Med, February 2006.
The nonsteroidal anti-inflammatory drug (NSAID) class has become large enough to form 3 subgroups: aspirin, the traditional NSAIDs, and the cylooxygenase-2 (COX-2)--inhibiting NSAIDs.
(It is conventional scientific wisdom that adverse drug reactions are grossly underreported.) In addition, the FDA from the start considered Zomax, the first nonsteroidal anti-inflammatory drug it approved, to be the only drug of its kind to pose a possible cancer risk to humans.
According to the company, Prolensa (bromfenac ophthalmic solution) 0.07% is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the treatment of postoperative inflammation and reduction of ocular pain in patients who have undergone cataract surgery.
Taking a nonsteroidal anti-inflammatory drug (NSAID) after a heart attack can increase the risk of death, recurrent heart attack, stroke and bleeding in patients taking antithrombotic therapy.
Taking a nonsteroidal anti-inflammatory drug (NSAID, such as aspirin, ibuprofen, or naproxen) may blunt the effectiveness of antidepressant medications, according to a report in the April 25 online edition of the Proceedings of the National Academy of Sciences.
The drug, marketed in the UK under the name Celebrex, is a nonsteroidal anti-inflammatory drug. It targets the enzyme cyclo-oxygenase 2, which is believed to be involved in the development of non-melanoma skin cancers triggered by too much sun exposure.
Roland: Would a nonsteroidal anti-inflammatory drug (NSAID) be as good as or better than a steroid in combination with an antibiotic?
Long-term use of a nonsteroidal anti-inflammatory drug is less likely to cause an ulcer after Helicobacter pylori is gone.
In 1989 the Food and Drug Administration approved the use of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for treating fever in children.