Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid
Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid
inhibit human Kvl.
Three LOX inhibitors, the non-specific inhibitor nordihydroguaiaretic acid
, the 5-LOX inhibitor Rev-5901 and the 12-LOX inhibitor baicalain were all found to inhibit in vitro and in vivo growth of pancreatic cancer cell lines as well as inducing apoptosis.
Also, a specific combination of OA and nordihydroguaiaretic acid
(NDGA) derived from Larrea divaricata was found to reduce acne by reversing keratinocyte multiplication, reduce inflammation by inhibiting prostaglandin synthesis, and inhibit growth of yeast and bacteria, all of which prevented the onset of acne.
(SIGMA Chemicals) was used as a positive control.
Finally, Session E, with moderator Linda Rhein, will feature "Synergies in combatting acne-prone skin: oleanic acid and nordihydroguaiaretic acid
inhibit 5-alpha reductase," "Cosmeceutical properties of fermented sage compound" and "Post adolescent acue: cosmetic relevance.
Erimos has exclusive license for nordihydroguaiaretic acid
(NDGA) derivatives from The Johns Hopkins University.