The polychromatic erythrocytes/ normochromatic
erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected.
Another 1000 erythrocytes were recorded separately and simultaneously met polychromatic erythrocytes (PCEs) and normochromatic
erythrocytes (NCEs) were counted to express NCE% and micronucleated normochromatic
In parallel, the relative proportion of PCE to normochromatic
erythrocytes (NCE) was analyzed in 1,000 erythrocytes.
The neoplastic cells were epithelioid and characterized by clear to granular, lightly eosinophilic cytoplasm and small, centrally located, normochromatic
, round to oval nuclei (Figure 2, A and B).
However, at the given doses, steviol caused significant reduction of polychromatic erythrocytes: normochromatic
erythrocytes (PCE:NCE) ratio of female hamsters at 72h, and rats and mice at 48 and 72h .
MNPCE: Micronucleated polychromatic erythrocyte, MNNCE: Micronucleated normochromatic
erythrocyte, SE: Standart error,
It should be noted that there are differences between scar tissue and fibroma-type tumoral tissue, as described by MOVASSAGHI & MOHAMMADI (2009), where the fibroma presents mature fusiform fibrocytes with oval normochromatic
nuclei and abundant collagen organized in bundles.
To determine the cytotoxic activity, we simultaneously computed 1000 normochromatic
erythrocytes and the polychromatic erythrocytes frequency.
To access the possible toxic effects of the treatments on erythropoisis percentage of polychromatic erythrocytes (PCE) was evaluated over 1000 total erythrocytes (PCE+NCE) (NCE = Normochromatic
The National Toxicology Program (NTP) report, 2007 showed that soluble chromate administered orally through drinking water induced a concentration-dependent increase in micronuclei in normochromatic
erythrocytes in am3-C57BL/6 male mice but only a small increase in micronuclei in [B6C3F.
It produces normocytic and normochromatic
red cells, but they also may be microcytic and hypochromic if the chronic disease produces iron deficiency (Thomas, 2004; Uphold & Graham, 2003).
MCV and MCHC are used to assess red cells as normochromatic
, hyperchromatic or hypochromatic.