novobiocin


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novobiocin

[‚nō·və′bī·ə·sən]
(microbiology)
C30H36O11N2 A moderately broad-spectrum antibiotic produced by strains of Streptomyces niveus and S. spheroides ; it is a dibasic acid and is converted either to the monosodium salt or to the calcium acid salt for pharmaceutical use.
References in periodicals archive ?
Antibiotic Carbenicillin Ampicillin Rifampicin Growth S R I Antibiotic Penicillin Tetracycline Polymyxin B Growth R R S Antibiotic streptomycin Chloramphenicol Growth R I Antibiotic Novobiocin Erythromycin Growth R S
2] /37 /37 Background + - DNA Gyrase Quinolones(d) + + Novobiocin (30) + - Folate metabolism Trimethoprim (5) + + Smx (25) + + DNA Metronidazole (50) - - Furazolidone (50) + + Cell envelope Cephalexin (30) + + Amoxycillin (25) + + Amoxy/Clav (20/10) +/- - Ampicillin (10) + + Pip/Taz (10/75) + + Imipenem (10) - - Aztreonam (30) + + Cefuroxime (5) + + Ceftazidime (30) + + Cefotaxime (30) + + Fosfomycin (200) - - Polymyxin B (300 IU) +/- - Translation Gentamicin (10) - - Chloramphenicol (30) - - Doxycycline (30) - - Erythromycin (15) - - Transcription Rifampin (25) - - Target of action Incubation conditions(b) Agent (disc content mg/L) [mO.
Now, Key characters are used for species and subspecies identification include colony morphology, oxygen requirements, coagulase, clumping factor, heat-stable nuclease, hemolysins, catalase, oxidase, alkaline phosphatase, urease, ornithine decarboxylase, pyrrolidonyl arylamidase, [beta]- galactosidase, acetoin production, nitrate reduction, esculin hydrolysis and aerobic acid production from a variety of carbohydrates including D-trehalose, Dmannitol, D-mannose, D-turanose, D-xylose, D-cellobiose, L-arabinose, maltose, -lactose, sucrose, and raffinose, and intrinsic resistance to novobiocin and polymyxin B [7].
Escherichia coli O157 samples were enriched in tryptic soy broth (TSB), exposed to an immunomagnetic separation step and then cultured on cefixime potassium tellurite sorbitol MacConkey (CT SMAC) and Rainbow agar containing novobiocin and tellurite (NT Rainbow) as previously described (Cooley et al.
For selective enrichment, Lab M's Mueller Kaufmann Tetrathionate Novobiocin Broth (MKTTn) is formulated to inhibit the growth of Proteus species and allow Salmonellae to thrive.
The antibiotics used for this test were Amoxyclav, Cephalexin, Ciproflaxacin, Clindamycin, Cloxacillin, Co-Trimaxazole, Erythromycin, Tetracyclin, Ampicillin, Carbenicilllin, Cephatoxamine, Chloramphenicol, Co-Trimazine, Gentamicin, Norflaxacin, Oxacillin, Amikacin, Bacitracin, Novobiocin, Vancomycin, Penicillin-G, Tobramycin, Cephaloridine, Kanamycin, Linomycin, Methicillin, Oleandomycin, Nalidixic acid, Sulphamethoxazole, Cefactor, Cefixime, Piperacillin and Cefoperazone.
Substrates of this pump include [beta]-lactams, [beta]-lactamase inhibitors, quinolones, macrolides, tetracyclines, chloramphenicol, novobiocin, sulfonamides, trimethoprim and thiolactomycin (9).
6) Staphylococcus aureus infections that colonize catheters and other indwelling medical devices were treated with the antibiotic novobiocin until drug-resistant S.