Focus is placed on two particular approaches, dynamic nuclear polarization
and para-hydrogen-driven polarization, exhibiting the highest potential for biophysical, metabolomic, pre-clinical and clinical research.
Another 27 studies consider such topics as fluctuations and relaxation dynamics of liquid water revealed by linear and nonlinear spectroscopy, charge transport at the metal-organic interface, ultrafast photochemistry in liquids, single-molecule fluorescence imaging in living cells, dynamic nuclear polarization
methods in solids and solutions to explore membrane proteins and membrane systems, and molecular switches and motors on surfaces.
The second section offers 12 chapters on recent developments, including high-frequency dynamic nuclear polarization
, homonuclear and heteronuclear dipolar recoupling, and relaxation studies of solid biopolymers.
Dynamic nuclear polarization
(DNP) is a technique that increases the sensitivity of NMR experiments by increasing the polarization of the more rarely occurring nuclei in a given sample.
Its real part makes the neutron spin rotate around the direction of the nuclear polarization
5 T), only achieve very modest nuclear polarization
(less than 0.
Dynamic Nuclear Polarization
can enhance the sensitivity of solid-state NMR by approximately two orders of magnitude, by transferring polarization from the electron spins to the nuclear spins.
Exploiting a unique equipment available in the host institution, the project aims to remove the current bottlenecks and develop improved dynamic nuclear polarization
(DNP)-enhanced ssNMR methodology to push forward the limits of applicability of this technique to macromolecular assemblies, opening new avenues to ssNMR in structural biology.
From the first come seven papers exploring conformational dynamics of oligosaccharides, structure and dynamics of carbohydrates using residual dipolar couplings, combined theoretical and NMR (nuclear magnetic resonance) experimental approach on carbohydrate-aromatic interactions and on pyranose ring distortion, laser photo chemically induced dynamic nuclear polarization
technique as a tool for structural analysis of inter- and intramolecular protein-carbohydrate interactions, and hydroxy protons in structural studies of carbohydrates by NMR spectroscopy.
At the polarization, the neutron and nuclear polarizations
are aligned in magnetic fields, while the neutron polarization must be aligned vertical to the nuclear polarization
for the measurement of the T-odd term.
Abingdon, UK 5/26/04 -- Oxford Instruments Superconductivity (OIS) has exclusively licensed in vitro fights to GE Healthcare's dynamic nuclear polarization
technology (DNP) for development of a new nuclear magnetic resonance (NMR) instrument.
Contract notice: Dynamic Nuclear Polarization
System and LOTS for DNP Coils (ITT/667).