The triple A syndrome is due to mutations in ALADIN, A novel member of the nuclear pore
Nuclear poly(A)-binding protein PABN1 is associated with RNA polymerase II during transcription and accompanies the released transcript to the nuclear pore
Recently, a group of researchers at Oxford University published a model for the structure of the nuclear pore
complex (NPC), the gatekeeper for the movement of molecules into and out of the nucleus (Alber et al.
The overall size of the CNH is too large to navigate the smaller (~40 nm dia) nuclear pore
For example, those proteins specific to the nuclear envelope and components of the nuclear pore
complexes, which allow the transport of large molecules to and from the nucleus, are cobbled together from protein domains specific to eubacteria and archaea, with various eukaryotic innovations.
Thus far, signal-mediated transport via pores has been demonstrated only for ultrafine gold particles of up to 39 nm in diameter, through the nuclear pore
complex in Xenopus oocytes, where transport velocities depended on particle size (Pante and Kann 2002).
Figure 1C shows a portion of a nucleus stained with antibodies to the nuclear pore
complex, followed by secondary antibodies that are conjugated to 0.
Beatty (1969); A large particle associated with the perimeter of the nuclear pore