Karyopharm is the first company to focus on discovering and developing therapies by targeting the nuclear pore
Recently, a group of researchers at Oxford University published a model for the structure of the nuclear pore
complex (NPC), the gatekeeper for the movement of molecules into and out of the nucleus (Alber et al.
For example, those proteins specific to the nuclear envelope and components of the nuclear pore
complexes, which allow the transport of large molecules to and from the nucleus, are cobbled together from protein domains specific to eubacteria and archaea, with various eukaryotic innovations.
Thus far, signal-mediated transport via pores has been demonstrated only for ultrafine gold particles of up to 39 nm in diameter, through the nuclear pore
complex in Xenopus oocytes, where transport velocities depended on particle size (Pante and Kann 2002).
Beatty (1969); A large particle associated with the perimeter of the nuclear pore
By providing evidence that Crm1p binds to certain proteins that form part of the nuclear pore
, Rosbash and his colleagues added another chapter to the Crm1p story.
The nuclear transport machinery plays an integral role in the regulation of many molecules involved in a broad spectrum of human and animal disease, and drug discovery has been enhanced with the recent determination of the 3-dimensional structure of the nuclear pore