nuclear receptor superfamily

nuclear receptor superfamily

[¦nü·klē·ər ri¦sep·tər ′sü·pər‚fam·lē]
(cell and molecular biology)
A large family of intracellular receptor proteins that bind to hydrophobic signal molecules (such as steroid and thyroid hormones) or intracellular metabolites and are thus activated to bind to specific DNA sequences, affecting transcription.
References in periodicals archive ?
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear receptor superfamily and was first identified in xenopus (Krey et al.
Liver X receptor agonists are members of the nuclear receptor superfamily that regulate multiple genetic pathways and demonstrate potent anti-inflammatory activity.
The actions of glucocorticoids are mediated by binding to the GR, a member of the nuclear receptor superfamily.
In addition, another study has indicated that PBDEs are able to induce the expression of CYP3A11- and CYP2B10-metabolizing enzymes by functioning as a ligand of pregnane X receptor (PXR), a member of the nuclear receptor superfamily (Pacyniak et al.
The VDR is a member of the nuclear receptor superfamily [3] that specifically binds to 1,25-dihydroxy vitamin D in target tissues stimulating intestinal calcium and phosphate absorption, and increasing bone resorption and renal calcium/phosphate reabsorption.
Peroxisome proliferator-activated receptors (PPARs) are members of a nuclear receptor superfamily which regulate gene expression and, thereby, controll energy metabolism.
The keynote lecture provides an introduction to the nuclear receptor superfamily and the remaining contributions discuss such topics as metabolic control by LXR receptors, regulation of cardiac energetic by the orphan nuclear receptors ERR-alpha and ERR-gamma, FXR and bile acids as critical modulators of metabolisms, the role of PPARs in human prediabetes, the role of the intestine in reverse cholesterol transport, NR4A nuclear receptors in the vessel wall, cholesterol as a novel target in the treatment of Alzheimer's disease, PPAR-gamma mediated effects in central nervous system disorders, and the role of the orphan nuclear receptor rev-erb-alpha in the molecular biology of circadian rhythms and cardiometabolic disease.
Studies which link in Utero exposures to such agents that result in permanent, alterations in gene expression in tissues of the reproductive system, the pulmono/cardiovascular system, the brain/nervous system, or the immune/autoimmune system leading to or resulting in cancer in those organ sites later in the adult life of the exposed fetus are sought by the NCI; 10) The NCI is also interested in funding research aimed at understanding the consequences of fetal exposure to toxicants, hormone agonists, or antagonists that alter the expression or function of the steroid nuclear receptor superfamily of genes (androgen, estrogen, progesterone, glucocorticoid, Vitamin D3, thyroxine) in normal or cancerous organs of the male and female reproductive tract and/or immune system.
Peroxisome proliferators exert their effects by activating the peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily.
Compared with other members of the nuclear receptor superfamily, PPARs have a spacious ligand-binding pocket (40) that allows them to be activated by diverse ligands, some of which, like DLCs, are polycyclic and lipophilic.
GR, a member of the nuclear receptor superfamily, mediates glucose homeostasis, immune modulation, cellular growth and differentiation, and numerous other physiological responses in a wide variety of tissues (33-36).
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